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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 680 to 699: 3 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Zhang M J Clin Microb 2005 | GGC/CGC | 2053 | 685 | Gly/Arg | 2005 | China | Sequencing. | Whole gene | H | 2ug/ml | BACTEC MGIT 960 | 1/87 | 1/0 | Ser315Thr in katG. | - |
| Pretorius GS AAC 1995 | GAC/GCC | 2084 | 695 | Asp/Ala | 1995 | South Africa | PCR-SSCP, Sequencing | - | HRS | 40 | Agar dilution method | 39/69 | 1/0 | - | - |
| Baker LV AAC 2005 | GGG/GAG | 2096 | 699 | Gly/Gln | 1998 | United Kingdom | Directed Oligonucleotide array, Sequencing | Whole gene | H,HS,HE,HSE,MDR | ratio>=4 | Resistance ratio method | 202/378 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |