Rv0129c: fbpCRv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1483: mabARv1484: inhARv1854c: ndhRv1592cRv1772Rv1908c: katG1909c: furARv2242: srm R homologRv2243: fabDRv2245: kasARv2247: accD6Rv2427A: oxyRRv2428: ahpCRv2846c: efpARv3139: fadE24Rv3566c: nhoARv3795: embB

Rv1908c

More about Rv1908c on    TBDB.org

More about Rv1908c on    TubercuList

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Display high confidence mutations only
Rv1908c: Codons 60 to 79: 12 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Siddiqi N AAC 2002 GCG/ACG 181 61 Ala/Thr 1995-1998 India Sequencing nt 3-239 & 1187-1600 HRO 10ug/ml R, 1ug/ml I, 2ug/ml O Proportion method 74/126 1/0 R463L KatG, S95T gyrA, S531L rpo -
Siddiqi N AAC 2002 ins C 185 62 Truncation 1995-1998 India Sequencing nt 3-239 & 1187-1600 HRS,HO,HR 10ug/ml R, 1ug/ml I 2ug/ml O Proportion method 74/126 3/0 S531W rpo, K121K rpsL, S95T gyrA,H526R rpo -
Rouse DA AAC 1995 GAC/GAA 189 63 Asp/Glu 1995 USA, South Korea PCR-SSCP, Sequencing Whole gene H 50ug/ml Absolute concentration method. 26/26 1/0 - -
Marttila HJ AAC 1996 ins CCCC 195 65 Frameshift 1989-1995 Finland Sequencing Whole gene H 1ug/ml Disk elution method 54/56 1/0 - -
Cockerill FR JID 1995 GCC/ACC 193 65 Ala/Thr 1995 USA PCR, RFLP, Sequencing. Whole gene H 0.25ug/ml Proportion method 40071 0/1 Ala66Pro and others in katG. -
Cockerill FR JID 1995 GCG/CCG 196 66 Ala/Pro 1995 USA Sequencing Whole gene H 0.25ug/ml Proportion method 40071 0/1 Ala65Thr, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr, Tyr337Phe -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ATC/AAC 212 71 Ile/Asn - - - - - - - - - - -
Chan RCY JAC 2007 GAC/GGC - 72 Asp/Gly 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Secondary Publication: Hazbon MH AAC 2006 GAC/AAC 214 72 Asp/Lys - - - - - - - - - - -
Siddiqi N AAC 2002 GAC/AAC ? 73 Asp/Asn 1995 India Sequencing nt 3-239 & 1187-1600 H 1ug/ml I Proportion method 74/126 1/0 R463L KatG -
Chan RCY JAC 2007 GAC/TAC 220 74 Asp/Tyr 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Chan RCY JAC 2007 GAC/GGC 221 74 Asp/Gly 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator