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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 600 to 619: 4 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Gagneux S PLOS Path 2006 | GAG/AAG | 1819 | 607 | Glu/Lys | - | - | - | - | - | - | - | - | - | - | - |
| Cockerill FR JID 1995 | ATG/ATT, ATG/ATC or ATG/ATA | 1827 | 609 | Met/Ile | 1995 | USA | PCR, RFLP, Sequencing. | Whole gene | H | <0.12-32ug/ml | Proportion method | - | - | "The 2 R isolates also had Arg463Leu + one other mutation each; the S isolate had no other mutations." | - |
| Marttila HJ AAC 1996 | ins AC | 1849 | 617 | Frameshift | 1989-1995 | Finland | Sequencing | Whole gene | H | 1 ug/ml | disk elution method | 54/56 | 1/0 | - | - |
| Wei CJ AAC 2003 | CTC/CCC | 1856 | 619 | Leu/Pro | 2003 | - | - | - | - | - | - | - | - | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |