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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 580 to 599: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Secondary Publication: Hazbon MH AAC 2006 | CTG/ATG | 1759 | 587 | Leu/Ile | - | - | - | - | - | - | - | - | - | - | - |
| Heym B MolMicro 1995 | CTG/ATG | 1759 | 587 | Leu/Met | 1995 | N.S. | PCR-SSCP, Sequencing | Whole gene | H | >5 ug/ml | Proportion method | 39/39 | 1/0 | - | - |
| Marttila HJ AAC 1996 | CTG/CCG | 1760 | 587 | Leu/Pro | 1989-1995 | Finland | Sequencing | Whole gene | H | 0.4ug/ml | disk elution method | 54/56 | 1/0 | - | - |
| Cockerill FR JID 1995 | CCC/ACC | 1765 | 589 | Pro/Thr | 1995 | USA | PCR, RFLP, Sequencing. | Whole gene | H | 32ug/ml | Proportion method | 40071 | 1/0 | Arg429Leu, Ala264Thr in katG. | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | GGC/GAC | 1778 | 593 | Gly/Asp | - | - | - | - | - | - | - | - | - | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |