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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 540 to 559: 3 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Cockerill FR JID 1995 | GCC/GAC | 1649 | 550 | Ala/Asp | 1995 | USA | Sequencing. | Whole gene | H | 0.12->32ug/ml | Proportion method | - | - | "R strain also Ala424Val; S strain also Gln224Glu, Ala243Ser." | - |
| Hai Hua Lin TubercRespirDis 2007 | GCC/GGC | 1652 | 551 | Ala/Gly | 2004 | South Korea | Sequencing | Whole gene | MDR | N.S. | N.S | 29/29 | 1/0 | None | - |
| Secondary Publication: Hazbon MH AAC 2006 | del C | 1667 | 556 | Frameshift | - | - | - | - | - | - | - | - | - | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |