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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 520 to 539: 4 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | ins ? | ? | 521 | Frameshift | - | - | - | - | - | - | - | - | - | - | - |
| Zhang M J Clin Microb 2005 | ins 64bp | 1559 | 521 | Frameshift | 2005 | China | Sequencing. | Whole gene | H | >256ug/ml | BACTEC MGIT 960 | 87/137 | 1/0 | "Arg463Leu in katG; also 1 mutation in oxy-ahpC, and 1 in efpA." | - |
| Marttila HJ AAC 1996 | CAG/CCG | 1574 | 525 | Gln/Pro | 1989-1995 | Finland | Sequencing | Whole gene | H | 0.4 ug/ml for I | disk elution method | 54/56 | 1/0 | - | - |
| Ramaswamy SV AAC 2003 | AAC/GAC | 1585 | 529 | Asn/Asp | 2003 | USA, Mexico, Central America, Southeast Asia, and Africa. | Sequencing | Whole gene | H | N/A | E-Test | 38/124 | 1/0 | katG Trp397Tyr, no other mutations in the 19 genes sequenced. | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |