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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 500 to 519: 6 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Hai Hua Lin TubercRespirDis 2007 | CAA/CAT | 1506 | 502 | Gln/His | 2004 | South Korea | Sequencing | Whole gene | MDR | N.S. | N.S | 29/29 | 1/0 | inhA -15 (C/T) | - |
| Abe C JCM 2008 | TGG/TCG | 1513 | 505 | Trp/Ser | Published in 2008 | Japan | Sequencing | Whole gene | H | - | MGIT 960 | 96/96 | 1/0 | - | - |
| Cockerill FR JID 1995 | TGG/CGG | 1513 | 505 | Trp/Arg | 1995 | USA | PCR, RFLP, Sequencing. | Whole gene | H | >32ug/ml | Proportion method | - | 1/0 | Tyr337Phe, Arg429Leu, Met609Ile | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | ins ? | ? | 511 | Frameshift | - | - | - | - | - | - | - | - | - | - | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | ins ? | ? | 513 | Frameshift | - | - | - | - | - | - | - | - | - | - | - |
| Zhang M J Clin Microb 2005 | CGC/TGC | 1543 | 515 | Arg/Cys | 2005 | China | Sequencing. | Whole gene | H | 8ug/ml | BACTEC MGIT 960 | 87/137 | 1/0 | Arg463Leu in katG. | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |