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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 480 to 499: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Baker LV AAC 2005 | CGT/AGT | 1450 | 484 | Arg/Ser | 1998 | United Kingdom | Directed Oligonucleotide array, Sequencing | Whole gene | H,HS,HE,HSE,MDR | ratio>=4 | Resistance ratio method | 202/378 | 1/0 | - | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | GGT/GTT | 1454 | 485 | Gly/Val | - | - | - | - | - | - | - | - | - | - | - |
| Marttila HJ AAC 1996 | G/C | 1464 | 488 | Lys/Asn | 1989-1995 | Finland | PCR, Sequencing. | Whole gene | H | >1ug/ml | Disk elution method. | 17/19 | 1/0 | katG Gln295STOP | - |
| Baker LV AAC 2005 | CGC/TGC | 1469 | 490 | Arg/Cys | 1998 | United Kingdom | Directed Oligonucleotide array, Sequencing | Whole gene | H,HS,HE,HSE,MDR | ratio>=4 | Resistance ratio method | 202/378 | 1/0 | - | - |
| Lavender C AAC 2005 | GGC/TGC | 1471 | 491 | Gly/Cys | 2001-2003 | Australia | Multiplex allele specific PCR assay | Whole gene | H | 0.4 ug/ml | BACTEC MGIT960 method | 52/104 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |