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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 440 to 459: 4 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Hai Hua Lin TubercRespirDis 2007 | GCG/ACG | 1330 | 444 | Ala/Thr | 2004 | South Korea | Sequencing | Whole gene | MDR | N.S. | N.S | 29/29 | 1/0 | None | - |
| Doustdar F MDR 2008 | CTC/TTC | 1345 | 449 | Leu/Phe | 2005-2006 | Iran | Sequencing | 250bp around 315 and 212 bp around 463, 238bp of inhA and 293bp of ahpC | H | N.S. | Proportion method | 48/93 | 1/0 | None | - |
| Bostanabad SZ Tuberk Torak 2007 | GAG/CGA | 1360 | 454 | Glu/Arg | 2004-2005 | Belarus | PCR, Sequencing. | 209-bp segment. | H | >1ug/ml | Proportion method, BACTEC | 42/42 | 2/0 | Most had 1-4 other katG mutations (most often in codon 315). | - |
| Bolotin S JAC 2009 | AGC/ATC | 1370 | 457 | Ser/Ile | 1999-2001 | Canada | Sequencing | codon 250-500 | H, HR | - | MGIT 960 | 154/504 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |