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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 420 to 439: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Cockerill FR JID 1995 | GCG/GAG | 1271 | 424 | Ala/Glu | 1995 | USA | PCR, RFLP, Sequencing. | Whole gene | H | <0.12ug/ml | Proportion method | - | 0/1 | Gln224Glu and Pro429Ser in katG. | - |
| Cockerill FR JID 1995 | GCG/GTG | 1271 | 424 | Ala/Val | 1995 | USA | PCR, RFLP, Sequencing. | Whole gene | H | >32ug/ml | Proportion method | - | 1/0 | 8-bp deletion in codon 10 + Ala550Asp in katG. | - |
| Cockerill FR JID 1995 | CCG/TCG | 1285 | 429 | Pro/Ser | 1995 | USA | PCR, RFLP, Sequencing. | Whole gene | H | <0.12ug/ml | Proportion method | - | 0/1 | Gln224Glu and Ala 424Glu in katG. | - |
| Ramaswamy SV AAC 2003 | CAG/TAG | 1300 | 434 | Gln/STOP | - | USA, Mexico | Sequencing | - | - | >256 | "BACTEC radiometric method (0.1ug/ml); E-test" | 38/121 | 1/0 | V163I (Rv0340) | - |
| Zhang M J Clin Microb 2005 | ins A | 1329 | 438 | Frameshift | 2005 | China | "IS6110-based RFLP; Sequencing." | Whole gene | H | - | BACTEC MGIT 960 | 1/87 | 1/0 | "Arg463Leu in katG; also 1 mutation in oxy-ahpC, and 1 in efpA." | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |