|
|
           
|
|
|
|
|
|
|
|
 
|
|
Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 40 to 59: 3 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Sekigushi J JCM 2007 | CTG/CAG | 143 | 48 | Leu/Gln | 2007 | Japan | Sequencing | Whole gene | - | - | Proportion method, BACTEC | 38/138 | 1/0 | -15C/T upstream of mabA | - |
| Baker LV AAC 2005 | del A | 149 | 50 | Frameshift | 1998 | United Kingdom | Directed Oligonucleotide array, Sequencing | Whole gene | H,HS,HE,HSE,MDR | ratio>=4 | Resistance ratio method | 202/378 | 1/0 | ahpC-34A | - |
| Pretorius GS AAC 1995 | del CCGTCGCTGACC | 157-168 | 52-57 | del Ala Val Ala Asp Pro | 1995 | USA | PCR-SSCP, Sequencing | 1-221, 202-338, 319-558, 541-741, 722-942, 923-1140, 1120-1342, 1323-1526, 1507-1718, 1699-1915, 1896-2115, 2096-2310 | HR | 1.0 ug/ml | Proportion method | 39/69 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
|
© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |