TBDReaMDB: INH: Rv1908c

Rv1908c

More about Rv1908c on TBDB.org

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Rv1908c: Codons 400 to 419: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Huang WL JCM 2009	del C	-	401	Frameshift	2007-2008	Taiwan	Sequencing	N.S.	242MDR	N.S.	MGIT 960	242/272	1/0	not mentiond	-
Pretorius GS AAC 1995	GCC/CGC	1225-1226	409	Ala/Arg	1995	South Africa	PCR-SSCP, Sequencing	-	HRSEryB	2.5 ug/ml	Agar dilution method	39/69	1/0	-	-
Chan RCY JAC 2007	GCC/GAC	1226	409	Ala/Asp	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	2	-
Huang WL JCM 2009	TAC/CAC	1237	413	Tyr/His	2007-2008	Taiwan	Sequencing	N.S.	242MDR	N.S.	MGIT 960	242/272	1/0	not mentiond	-
Bolotin S JAC 2009	AAG/AAC	1242	414	Lys/Asn	1999-2001	Canada	Sequencing	codon 250-500	H, HR	-	MGIT 960	154/504	1/0	-	-
Ghiladi RA J Am Chem Soc 2005	CGA/CTA	1253	418	Arg/Leu	-	-	-	-	-	-	-	-	-	-	-
Mo L Microb Drug Res 2004	CGA/CAA	1253	418	Arg/Gln	-	-	-	-	-	-	-	-	-	-	-
Huang WL JCM 2009	GAC/CAC	1255	419	Asp/His	2007-2008	Taiwan	Sequencing	N.S.	242MDR	N.S.	MGIT 960	242/272	1/0	not mentiond	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.