TBDReaMDB: INH: Rv1908c

Rv1908c

More about Rv1908c on TBDB.org

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Rv1908c: Codons 380 to 399: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Chan RCY JAC 2007	ACT/ATT	1139	380	Thr/Ile	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	2	-
Rouse et al MM 1996	GAC/GGC	1142	381	Asp/Gly	1996	-	-	-	-	-	N.S.	n/a	-	-	-
Gagneux S PLOS Path 2006	CTG/CGG	1151	384	Leu/Arg	-	-	-	-	-	-	-	-	-	-	-
Chan RCY JAC 2007	ACT/ATT	1169	390	Thr/Ile	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	2	-
Sekigushi J JCM 2007	ins CTA	1170	390	ins Leu	2007	Japan	Sequencing	Whole gene	-	-	Proportion method, BACTEC	38/138	2/0	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	ATC/AAC	1178	393	Ile/Asn	-	-	-	-	-	-	-	-	-	-	-
Gagneux S PLOS Path 2006	ACG/GCG	1180	394	Thr/Ala	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Hazbon MH AAC 2006	TGG/TAG	1191	397	Trp/STOP	-	-	-	-	-	-	-	-	-	-	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.