Rv0129c: fbpCRv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1483: mabARv1484: inhARv1854c: ndhRv1592cRv1772Rv1908c: katG1909c: furARv2242: srm R homologRv2243: fabDRv2245: kasARv2247: accD6Rv2427A: oxyRRv2428: ahpCRv2846c: efpARv3139: fadE24Rv3566c: nhoARv3795: embB

Rv1908c

More about Rv1908c on    TBDB.org

More about Rv1908c on    TubercuList

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Display high confidence mutations only
Rv1908c: Codons 340 to 359: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Morlock GP AAC 2003 TGG/TCG 1022 341 Trp/Ser 2003 Brazil Sequencing fragment encompassing codons 249 to 342 HEth 5o Eth, >32 I Microplate alamar blue assay 17/41 1/0 4463S ethA, C(-15)T inhA regulator -
Gagneux S PLOS Path 2006 AAG/ACG 1034 345 Lys/Thr - - - - - - - - - - -
Chan RCY JAC 2007 del G - 346 Frameshift 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 2 -
Rouse et al MM 1996 GCT/ACT 1048 350 Ala/Thr 1996 - - - - - N.S. n/a - - -
Rouse DA AAC 1995 GCT/TCT 1048 350 Ala/Ser 1995 - PCR SSCP Whole gene H 1 ug/ml Absolute concentration method 26/26 1/0 - -
Boonaiam S CMI 2009 CAA/TAA 1054 352 Gln/STOP 2005-2006 Thailand Sequencing Whole gene MDR >=1ug/ml for I Disk elution method 160/170 1/0 - -
Bostanabad SZ Tuberk Torak 2007 GAC/CAC 1069 357 Asp/His 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 1/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GAC/AAC 1069 357 Asp/Asn 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 1/0 Most had 1-4 other katG mutations (most often in codon 315). -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator