TBDReaMDB: INH: Rv1908c

Rv1908c

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Rv1908c: Codons 320 to 339: 18 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Chan RCY JAC 2007	TGG/CGG	961	321	Trp/Arg	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	3	-
Bostanabad SZ Tuberk Torak 2007	TGG/TAG	961	321	Trp/STOP	2004-2005	Belarus	PCR, Sequencing.	209-bp segment.	H	>1ug/ml	Proportion method, BACTEC	42/42	2/0	Most had 1-4 other katG mutations (most often in codon 315).	-
Bostanabad SZ Tuberk Torak 2007	TGG/TTG	962	321	Trp/Leu	2004-2005	Belarus	PCR, Sequencing.	209-bp segment.	H	>1ug/ml	Proportion method, BACTEC	42/42	2/0	Most had 1-4 other katG mutations (most often in codon 315).	-
Bostanabad SZ Tuberk Torak 2007	TGG/TCC	962-963	321	Trp/Ser	2004-2005	Belarus	PCR, Sequencing.	209-bp segment.	H	>1ug/ml	Proportion method, BACTEC	42/42	1/0	Most had 1-4 other katG mutations (most often in codon 315).	-
Bostanabad SZ Tuberk Torak 2007	TGG/TGT	963	321	Trp/Cys	2004-2005	Belarus	PCR, Sequencing.	209-bp segment.	H	>1ug/ml	Proportion method, BACTEC	42/42	1/0	Most had 1-4 other katG mutations (most often in codon 315).	-
No publication listed	ACC/CCC	970	324	Thr/Pro	-	-	-	-	-	-	-	-	-	-	-
Musser JM JID 1996	TGG/GGG	982	328	Trp/Gly	1996	-	Sequencing	Whole gene	HR	>=1ug/ml for I	Proportion method	34/46	1/0	-	-
Haas WA AAC 1997	TGG/TTG	983	328	Trp/Leu	1997	Free state, Lesotho, Eastern Cape, Natal, Swaziland, Gauteng	PCR-RFLP	894 bp central fragment of katG	H	-	-	124/212	1/0	-	-
Boonaiam S CMI 2009	TGG/TCG	984	328	Trp/Ser	2005-2006	Thailand	Sequencing	Whole gene	MDR	>=1ug/ml for I	Disk elution method	160/170	1/0	-	-
Haas WA AAC 1997	TGG/TGC	984	328	Trp/Cys	1997	Free state, Lesotho, Eastern Cape, Natal, Swaziland, Gauteng	PCR-RFLP	894 bp central fragment of katG	H	-	-	124/212	1/0	-	-
Bostanabad SZ Tuberk Torak 2007	TGG/TGT	984	328	Trp/Cys	2004-2005	Belarus	PCR, Sequencing.	209-bp segment.	H	>1ug/ml	Proportion method, BACTEC	42/42	4/0	Most had 1-4 other katG mutations (most often in codon 315).	-
Zenteno-Cuevas R MemInstOswaldCruz 2009	AGT/TGT	991	331	Ser/Cys	2007	Mexico	Sequencing	codon 240-390 of katG	HRS	N.S.	BACTEC 460	17/25	1/0	katG S315T	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	-	See Note	334	Ile/Thr Error	-	-	-	-	-	-	-	-	-	-	-
Rouse DA AAC 1995	ATC/ACC	1004	335	Ile/Thr	-	-	-	-	-	-	-	-	-	-	-
Lipin MY CMI 2007	ATC/GTC	1003	335	Ile/Val	1998-2001	Russia	Sequencing	nt 872-1568	HRS	1 ug/ml I, 5 ug/ml S, 20ug/ml R	Absolute concentration method	217/217	1/0	315 AGC/AGA katG	-
Lee ASG AAC 1999	CTG/CGG	1007	336	Leu/Arg	-	-	-	-	-	-	-	-	-	-	-
Cockerill FR JID 1995	TAC/TTC	1010	337	Tyr/Phe	1995	USA	PCR, RFLP, Sequencing.	Whole gene	H	0.25ug/ml	Proportion method	-	-	Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr	-
Cockerill FR JID 1995	TAC/TGC	1010	337	Tyr/Cys	1995	USA	PCR, RFLP, Sequencing.	Whole gene	H	1ug/ml	Proportion method	-	1/0	Arg429Leu, Trp505Arg, Met609Ile	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.