Rv0129c: fbpCRv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1483: mabARv1484: inhARv1854c: ndhRv1592cRv1772Rv1908c: katG1909c: furARv2242: srm R homologRv2243: fabDRv2245: kasARv2247: accD6Rv2427A: oxyRRv2428: ahpCRv2846c: efpARv3139: fadE24Rv3566c: nhoARv3795: embB

Rv1908c

More about Rv1908c on    TBDB.org

More about Rv1908c on    TubercuList

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Display high confidence mutations only
Rv1908c: Codons 300 to 319: 36 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Lee ASG AAC 1999 TGG/TAA or TGG/TAG or TGG/TGA - 300 Trp/STOP 1994-1996 Singapore Sequencing Whole gene H 0.1 ug/ml BACTEC 460 160/192 - - -
Marttila HJ AAC 1996 TGG/GGG 898 300 Trp/Gly 1989-1995 Finland Sequencing Whole gene H 1 ug/ml Disk elution method 54/56 1/0 - -
Gagneux S PLOS Path 2006 ins T 901-902 301 Frameshift - - - - - - - - - - -
Cockerill FR JID 1995 AGC/AGG 906 302 Ser/Arg 1995 USA Sequencing Whole gene H 8ug/ml Proportion method 40071 1/0 Ser315Thr and Arg463Leu in katG. -
Bolotin S JAC 2009 TAT/TCT 911 304 Tyr/Ser 1999-2001 Canada Sequencing codon 250-500 H, HR - MGIT 960 154/504 1/0 - -
Bostanabad SZ Tuberk Torak 2007 GGC/GCC 913 305 Gly/Ala 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 3/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GGA/CGA 919 307 Gly/Arg 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 1/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GGA/GCA 920 307 Gly/Ala 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Ramaswamy SV J Med Micro 2004 GGA/GAA 920 307 Gly/Glu 1996-1998 Mexico Directed Oligonucleotide array, Sequencing codon 228-357 HRSE >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E Proportion method 37/50 1/0 Ser450Leu rpoB, -
Khadka DK Southest Asian J Trop Med Public Health 2007 ACC/CCC 922 308 Thr/Pro 2007 Bangkok PCR-SSCP, Sequencing 894 bp fragment encompassing codons 254 to 549 HRSEO - - 29/30 1/0 Arg463Leu katG, C(-15)T inhA -
Bostanabad SZ Tuberk Torak 2007 GGT/GTT 926 309 Gly/Cys 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GGT/GCT 926 309 Gly/Ser 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Kim SY Diagn Micro Inf Dis 2003 GGT/GAT 926 309 Gly/Asp 200-2002 South Korea PCR-SSCP, Sequencing 210 bp fragment spanning codon 315 HR 0.2 ug/ml I 40 ug/ml R Proportion method 71/97 2/0 inhA Ribosomal binding site C/T -
Bostanabad SZ Tuberk Torak 2007 GGT/GTC 926-927 309 Gly/Phe 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Huang WL JCM 2009 del A 928-929 310 Frameshift 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Bostanabad SZ Tuberk Torak 2007 GAC/TAC 931 311 Asp/Tyr 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GAC/TTC 931-932 311 Asp/Phe 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Chan RCY JAC 2007 GAC/GGC 932 311 Asp/Gly 2007 Hong Kong PCR-SSCP, Sequencing 703 bp fragment HEP 1ug/ml I, 4ug/ml E, 100ug/ml P Absolute concentration method, BACTEC MGIT 960 241/302 1/0 574Ser/Leu rpoB -
Zenteno-Cuevas R MemInstOswaldCruz 2009 GAC/GAG 933 311 Asp/Glu 2007 Mexico Sequencing codon 240-390 of katG HREZ N.S. BACTEC 460 17/25 1/0 katG S315T -
Bostanabad SZ Tuberk Torak 2007 ACC/AAC 941 314 Ser/Asn 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 ACC/ACG 941-942 314 Ser/Thr 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Haas WA AAC 1997 AGC/CGC 943 315 Ser/Arg 1997 South Africa PCR-RFLP 894 bp central fragment of katG? H - - 124/212 1/0 - -
Marttila HJ AAC 1996 AGC/CTA 943 315 Ser/Leu 1989-1995 Finland Sequencing Whole gene HS >1ug/ml Disk elution method. 17/19 1/0 katG Pro501Ala. -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/GGC 943 315 Ser/Gly - - - - - - - - - - -
Musser JM JID 1996 AGC/ACC 944 315 Ser/Thr - - - - - - - - - - -
Haas WA AAC 1997 AGC/ATC 944 315 Ser/Ile 1997 Sierra Leone, Lesotho PCR-RFLP 892 bp central fragment HRSEth,H - - 124/212 4/0 -
Haas WA AAC 1997 AGC/AAC 944 315 Ser/Asn 1997 Free state, Gauteng, Sierra leone PCR-RFLP 890 bp fragment H,HRE,HR - - 124/212 9/0 -
Heym B MolMicro 1995 AGC/ACC 944 315 Ser/Thr 1995 Mali Ivory coast, France PCR-SSCP, Sequencing Whole gene H 1 in 4 and >5 in 1 Proportional method 34/37 5/0 -
Marttila HJ AAC 1996 AGC/ACA 944-945 315 Ser/Thr 1989-1995 Finland Sequencing Whole gene HS,HRS 1 ug/ml for I Disk elution method. 54/56 2/0 nt1501G/C katG in one
Gagneux S PLOS Path 2006 AGC/ACG 944-945 315 Ser/Thr - - - - - - - - - - -
Lipin MY CMI 2007 AGC/AGA 945 315 Ser/Arg 1998-2001 Russia Sequencing nt 872-1568 HRS 1 ug/ml I, 5 ug/ml S, 20ug/ml R Absolute concentration method 217/217 2/0 335 /GTC katG in one
Secondary Publication: Hazbon MH AAC 2006 AGC/AGG 945 315 Ser/Arg - - - - - - - - - - -
Bostanabad SZ Tuberk Torak 2007 GGC/AGC 946 316 Gly/Ser 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 18/0 Most had 1-4 other katG mutations (most often in codon 315). -
Secondary Publication: Hazbon MH AAC 2006 GGC/GAC 947 316 Gly/Asp - - - - - - - - - - -
Chan RCY JAC 2007 ATC/CTC 949 317 Ile/Leu 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 2 -
Zenteno-Cuevas R MemInstOswaldCruz 2009 GAG/GTA 953-954 318 Gly/Val 2007 Mexico Sequencing codon 240-390 of katG HRSEZ N.S. BACTEC 460 17/25 1/0 katG S315T -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator