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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 280 to 299: 10 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Gagneux S PLOS Path 2006 | CCG/CAT or CCG/CAC | 839-840 | 280 | Pro/His | - | - | - | - | - | - | - | - | - | - | - |
| Cockerill FR JID 1995 | GCC/GTC | 842 | 281 | Ala/Val | 1995 | USA | Sequencing | Whole gene | H | 1ug/ml | Proportion method | - | 1/0 | Pro2Ser, Ser17Asn, Met126Ile, Gly169Ala, Gln224Glu, Ala264Val, Try337Cys, Arg463Leu | - |
| Abe C JCM 2008 | GGC/GAC | 854 | 285 | Gly/Asp | Published in 2008 | Japan | Sequencing | Whole gene | H | - | MGIT 960 | 96/96 | 1/0 | - | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | ins | ? | 289 | Frameshift? | - | - | - | - | - | - | - | - | - | - | - |
| Chan RCY JAC 2007 | GAG/GAC | 867 | 289 | Glu/Asp | 1994-2004 | Hong Kong | PCR-SSCP, Sequencing | Whole gene | N.S. | - | Absolute concentration method | 250 | 241 | 1 | - |
| Fang Z JCM 1999 | GCT/CCT | 871 | 291 | Ala/Pro | 1990-1997 | United Kingdom | PCR-SSCP, Sequencing | - | HR | - | BACTEC | 10/715 | 1/0 | His 526Tyr rpoB | - |
| Sekigushi J JCM 2007 | CAG/CCG | 884 | 295 | Gln/Pro | 2007 | Poland | Sequencing | Whole gene | - | - | Proportion method, BACTEC | 38/138 | 1/0 | - | - |
| Sekigushi J JCM 2007 | GGC/GTC | 890 | 297 | Gly/Val | 2007 | Poland | Sequencing | Whole gene | - | - | Proportion method, BACTEC | 38/138 | 1/0 | - | - |
| Chan RCY JAC 2007 | GGC/TGC | 895 | 299 | Gly/Cys | 1994-2004 | Hong Kong | PCR-SSCP, Sequencing | Whole gene | N.S. | - | Absolute concentration method | 250 | 241 | 1 | - |
| Huang WL JCM 2009 | GGC/GCC | 896 | 299 | Gly/Ala | 2007-2008 | Taiwan | Sequencing | N.S. | 242MDR | N.S. | MGIT 960 | 242/272 | 1/0 | not mentiond | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |