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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 260 to 279: 7 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Rouse DA AAC 1995 | ACA/AGA | 785 | 262 | Thr/Arg | 1995 | USA, South Korea | PCR-SSCP, Sequencing | Whole gene | H | 1 ug/ml | Absolute concentration method | 26/26 | 1/0 | - | - |
| Cockerill FR JID 1995 | GCG/ACG | 790 | 264 | Ala/Thr | 1995 | USA, Japan | Sequencing | Whole gene | - | "0.25; catalase 14mm" | "Middlebrook 7H11 agar; 1% Proportion method" | - | 1/0 | Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Tyr337Phe | - |
| Chan RCY JAC 2007 | del G | - | 268 | Frameshift | 1994-2004 | Hong Kong | PCR-SSCP, Sequencing | Whole gene | N.S. | - | Absolute concentration method | 250 | 241 | 1 | - |
| Pretorius GS AAC 1995 | ACC/GCC | 820 | 275 | Thr/Ala | 1995 | South Africa, Switzerland | PCR-SSCP, Sequencing | Whole gene? | HR,HRSEEryB | 10 & >2.5 ug/ml | Agar dilution method | 39/69 | 2/0 | - | - |
| Heym B MolMicro 1995 | ACC/CCC | 823 | 275 | Thr/Pro | 1995 | France | PCR-SSCP, Sequencing | Whole gene | HMDR | > 10 ug/ml | Proportion method | 34/37 | 1/0 | - | - |
| Ramaswamy SV J Med Micro 2004 | ACC/TCC | 823 | 275 | Thr/Ser | 1996-1998 | Mexico | Directed Oligonucleotide array, Sequencing | codon 228-357 | HR | >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E | Proportion method | 37/50 | 1/0 | His445Asp rpoB, | - |
| Morlock GP AAC 2003 | GGC/GAC | 836 | 279 | Gly/Asp | 2003 | Brazil | Sequencing | fragment encompassing codons 249 to 342 | HEth | >32 I, >200 Eth | Microplate alamar blue assay | 17/41 | 1/0 | D55/A ethA,L44L inhA ORF, C(-15)T inhA regulator |  |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |