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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 240 to 259: 8 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Baker LV AAC 2005 | CCC/CCG | 723 | 241 | Pro/Pro | 1998 | United Kingdom | Directed Oligonucleotide array, Sequencing | Whole gene | H,HS,HE,HSE,MDR | ratio>=4 | Resistance ratio method | 202/378 | 2/0 | - | - |
| Cockerill FR JID 1995 | GCC/TCC | 727 | 243 | Ala/Ser | 1995 | USA, Japan | Sequencing | Whole gene | - | "0.12; catalase 28mm" | "Middlebrook 7H11 agar; 1% Proportion method" | - | 1/0 | Pro2Ser, Ser17Asn, Gly19Asp, Gln224Glu, Ala550Asp | - |
| Ramaswamy SV J Med Micro 2004 | CGC/TGC | 745 | 249 | Arg/Cys | 1996-1998 | Mexico | Directed Oligonucleotide array, Sequencing | codon 228-357 | HRSE | >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E | Proportion method | 37/50 | 2/0 | His445Tyr rpoB, Lys43Arg rpsL, Met306Ile embB | - |
| Gagneux S PLOS Path 2006 | ACG/ATG | 752 | 251 | Thr/Met | - | - | - | - | - | - | - | - | - | - | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | TTT/CTT | 754 | 252 | Phe/Leu | - | - | - | - | - | - | - | - | - | - | - |
| Sekigushi J JCM 2007 | ATG/ACG | 770 | 257 | Met/Thr | 2007 | Japan, Poland | Multiplex Sequencing | Whole gene | - | - | Middlebrook 7H10 agar medium method Ogawa egg based medium method, Rapid broth method(BACTEC) | 38/138 | 1/0 | R463L V780P katG, -15C/T upstream of mabA | - |
| Lavender C AAC 2005 | ATG/ATT | 771 | 257 | Met/Ile | 2001-2003 | Australia | Multiplex allele specific PCR Assay | Whole gene | HR | 0.1ug/ml I, 1ug/ml R | BACTEC MGIT960 | 52/104 | 1/0 | - | - |
| Cockerill FR JID 1995 | AAC/AGC | 773 | 258 | Asn/Ser | 1995 | USA | Sequencing. | Whole gene | H | 0.25ug/ml | Proportion method | - | 0/1 | Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Ala264Thr, Tyr337Phe | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |