TBDReaMDB: INH: Rv1908c

Rv1908c

More about Rv1908c on TBDB.org

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Rv1908c: Codons 220 to 239: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Cockerill FR JID 1995	CAG/GAG	670	224	Gln/Glu	1995	USA, Japan	Sequencing	Whole gene	-	"1; catalase 8 mm"	Proportionmethod	-	1/0	Pro2Ser, Ser17Asn, Met126Ile, Gly169Ala, Ala264Val, Ala281Val, Try337Cys, Arg463Leu	-
Cockerill FR JID 1995	CAG/GAG	670	224	Gln/Glu	1995	USA	Sequencing	Whole gene	H	<0.12-1ug/ml	Proportion method	-	39815	Ala424Glu, Pro429Ser	-
Ghiladi RA J Am Chem Soc 2005	TAC/TTC	686	229	Tyr/Phe	-	-	-	-	-	-	-	-	-	-	-
Chan RCY JAC 2007	GTG/GCG	689	230	Val/Ala	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Baker LV AAC 2005	GGG/GAG	701	234	Gly/Glu	1998	United Kingdom	Directed Oligonucleotide array, Sequencing	Whole gene	H,HS,HE,HSE,MDR	ratio>=4	Resistance ratio method	202/378	1/0	-	-
Chan RCY JAC 2007	GGG/AGG	700	234	Gly/Arg	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Chan RCY JAC 2007	AAC/ACC	707	236	Asn/Thr	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Hai Hua Lin TubercRespirDis 2007	AAC/AAG	714	238	Asn/Lys	2004	South Korea	Sequencing	Whole gene	MDR	N.S.	N.S	29/29	1/0	katG S140R	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.