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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 20 to 39: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Ramaswamy SV J Med Micro 2004 | del | 85-1059 | 29-353 | Truncation | 1996-1998 | Mexico | Directed Oligonucleotide array, Sequencing | codon 228-357 | H,R,E | >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E | Proportion method | 37/50 | 1/0 | "nt 1238; T-C rrs " | - |
| Siddiqi N AAC 2002 | ins A | 98 | 33 | Truncation | 1995-1998 | India | Sequencing | nt 3-239 & 1187-1600 | HR,HRS | 10ug/ml R, 1ug/ml I | Proportion method | 74/126 | 4/0 | S531W rpo, H526L rpo, R463L KatG, D516G rpo, H526R rpo | - |
| Siddiqi N AAC 2002 | AAC/GAC | 103 | 35 | Asn/Asp | 2002 | India | Sequencing. | 237bp + 414bp fragments | I,IRSO | >1ug/ml | Proportion method | 74/126 | 2/0 | "One mutant at katG Arg463Leu; both mutant at rpoB Asp516Val." | - |
| Siddiqi N AAC 2002 | del G | 109 | 37 | TRUNC 45aa | 1995 | India | Sequencing | nt 3-239 & 1187-1600 | HRO,HR | 10ug/ml R, 1ug/ml I 2ug/ml O | Proportion method | 74/126 | 2/0 | S531W rpo, S95T gyrA, L511L H526R rpo | - |
| Secondary Publication: Hazbon MH AAC 2006 | TGG/TGA | 114 | 38 | Trp/STOP | - | - | - | - | - | - | - | - | - | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |