TBDReaMDB: INH: Rv1908c

Rv1908c

More about Rv1908c on TBDB.org

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Rv1908c: Codons 180 to 199: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Secondary Publication: Hazbon MH AAC 2006	ACG/AAG	539	180	Thr/Lys	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	ACG/???	See Note	180	Thr/Cys	-	-	-	-	-	-	-	-	-	-	-
Chan RCY JAC 2007	GGC/GTC	557	186	Gly/Val	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Chan RCY JAC 2007	GGC/CAC	556-557	186	Gly/His	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Baker LV AAC 2005	TGG/CGG	571	191	Trp/Arg	1998	United Kingdom	Directed Oligonucleotide array, Sequencing	Whole gene	H,HS,HE,HSE,MDR	ratio>=4	Resistance ratio method	202/378	1/0	-	-
Chan RCY JAC 2007	del G	572	191	Frameshift	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Morlock GP AAC 2003	G/A	583	195	Glu/Lys	2003	USA	Sequencing	Whole gene	Eth	1	Microplate alamar blue assay	17/41	0/1	nt 280 T/G inh ORF	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	TGG/TGA	594	198	Trp/STOP	-	-	-	-	-	-	-	-	-	-	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.