TBDReaMDB: INH: Rv1908c

Rv1908c

More about Rv1908c on TBDB.org

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Rv1908c: Codons 160 to 179: 6 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	TCA/TTA	479	160	Ser/Leu	-	-	-	-	-	-	-	-	-	-	-
Gagneux S PLOS Path 2006	GCG/ACG	484	162	Ala/Thr	-	-	-	-	-	-	-	-	-	-	-
Cockerill FR JID 1995	GGC/GCC	506	169	Gly/Ala	1995	USA	Sequencing.	Whole gene	H	1ug/ml	Proportion method	40071	1/0	Pro2Ser, Ser17Asn, Met126Ile, Gln224Glu, Ala264Val, Ala281Val, Try337Cys, Arg463Leu	-
Secondary Publication: Hazbon MH AAC 2006	GCG/ACG	514	172	Ala/Thr	2006	USA, Spain	HP asay, molecular beacon assay, Sequencing	-	H	0.2ug/ml proportion method, 0.1 for BACTEC methods	Agar Proportion method, BACTEC MGIT 960, BACTEC 460	403/1111	2/0	-	-
Chan RCY JAC 2007	GCG/GTG	515	172	Ala/Val	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Chan RCY JAC 2007	ATG/ATA	528	176	Met/Ile	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	3	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.