TBDReaMDB: INH: Rv1908c

Rv1908c

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Rv1908c: Codons 140 to 159: 12 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	AGC/GCC?	418-419?	140	Ser/Ala	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	AGC/AAC	419	140	Ser/Asn	2006	USA, Spain	HP asay, molecular beacon assay, Sequencing	-	-	0.2ug/ml proportion method, 0.1 for BACTEC methods	Proportion method, BACTEC MGIT 960, BACTEC 460	403/1111	9/0	-	-
Secondary Publication: Hazbon MH AAC 2006	AGC/GGC	418	140	Ser/Gly	-	-	-	-	-	-	-	-	-	-	-
Hai Hua Lin TubercRespirDis 2007	AGC/AGA	420	140	Ser/Arg	2004	South Korea	Sequencing	Whole gene	MDR	N.S.	N.S	29/29	1/0	katG N238K	-
Sekigushi J JCM 2007	TTG/TTC	423	141	Leu/Phe	2007	Japan, Poland	Sequencing	Whole gene	-	-	Proportionmethod, BACTEC MGIT 960	38/138	2/0	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	GAC/GCC	425	142	Asp/Ala	-	-	-	-	-	-	-	-	-	-	-
Gagneux S PLOS Path 2006	AAG/ACG	428	143	Lys/Thr	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	CTG/GCG	443	148	Leu/Ala	-	-	-	-	-	-	-	-	-	-	-
Rouse et al MM 1996	CTG/CGG	443	148	Leu/Arg	1996	-	-	-	-	-	N.S.	n/a	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	CCG/GCG?? See Note	See Note	150	Leu/Ala Error? See Note	-	-	-	-	-	-	-	-	-	-	-
Marttila HJ AAC 1998	TAC/TCC	464	155	Tyr/Ser	1993-1995	Russia	Sequencing.	Whole gene	HRSK	1 ug/ml I, 5 ug/ml R	Proportionmethod	24/27	1/0	Arg463Leu katG, Ser 531Leu rpoB	-
Gagneux S PLOS Path 2006	TAC/TGC	464	155	Tyr/Cys	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	3	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.