TBDReaMDB: INH: Rv1908c

Rv1908c

More about Rv1908c on TBDB.org

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Rv1908c: Codons 120 to 139: 17 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	del	?	120	Frameshift?	-	-	-	-	-	-	-	-	-	-	-
Heym B MolMicro 1995	del	358-369	120-123	del	1995	Yugoslavia	PCR-SSCP, Sequencing	Whole gene	H	-	Proportion method	34/37	2/0	-	-
Gagneux S PLOS Path 2006	GGC/TGC	361	121	Gly/Cys	-	-	-	-	-	-	-	-	-	-	-
Marttila HJ AAC 1998	GGC/GTC	362	121	Gly/Val	1993-1995	Russia	Sequencing.	Whole gene	HR	N/A	Proportion method	24/27	1/0	Asp516Val in rpoB	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	del	?	122	Frameshift?	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	del	?	123	Frameshift?	-	-	-	-	-	-	-	-	-	-	-
Ramaswamy SV AAC 2003	ins G	372	124	Frameshift	-	USA, Mexico	Sequencing	-	-	>256	BACTEC 460, E-test	38/121	1/0	G-9A (oxyR-ahpC)	-
Chan RCY JAC 2007	GGC/TGC	373	125	Gly/Cys	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Heym B MolMicro 1995	ins CAT	373-375	125	ins His	1995	Yugoslavia	PCR-SSCP, Sequencing	Whole gene	H	-	Proportion method	34/37	1/0	-	-
Cockerill FR JID 1995	ATG/ATT, ATG/ATC or ATG/ATA	378	126	Met/Ile	1995	USA, Japan	Sequencing	Whole gene	-	".025; catalase 14 mm"	Proportion method	40071	1/0	"A65T; A66P; A243S; N258S; A264T; Y337F"	-
Chan RCY JAC 2007	CAG/CCG	380	127	Gln/Pro	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Fang Z JCM 1999	CGG/CCG	384	128	Arg/Pro	1990-1997	United Kingdom	PCR-SSCP, Sequencing	2268-2288&2595-2615, 2781-2801&3115-3135, 3366-3386& 3633-3653, 3661-3681& 3973-3993	H,E,R,P,Rifa,Cip,Ami,S,Proth	-	BACTEC 460	10/715	1/0	Leu511Pro rpoB	-
Hazbon MH AAC 2006	AAC/CAC	412	138	Asn/His	2006	USA, Spain	HP asay, molecular beacon assay, Sequencing	-	H	0.2ug/ml proportion method, 0.1 for BACTEC methods	Proportion method, BACTEC MGIT 960, BACTEC 460	403/1111	1/0	-	-
Hazbon MH AAC 2006	AAC/GAC	412	138	Asn/Asp	2006	USA, Spain	HP asay, molecular beacon assay, Sequencing	-	H	0.2ug/ml proportion method, 0.1 for BACTEC methods	Proportion method, BACTEC MGIT 960, BACTEC 460	403/1111	2/0	-	-
Hazbon MH AAC 2006	AAC/AGC	413	138	Asn/Ser	2006	USA, Spain	HP asay, molecular beacon assay, Sequencing	-	H	0.2ug/ml proportion method, 0.1 for BACTEC methods	Proportion method, BACTEC MGIT 960, BACTEC 460	403/1111	1/0	-	-
Morlock GP AAC 2003	AAC/ACC	413	138	Asn/Thr	2003	USA, Russia, Brazil	Sequencing	Whole gene	H	>32ug/ml	Microplate alamar blue assay method	17/41	1/0	-	-
Wei CJ AAC 2003	GCC/CCC	415	139	Ala/Pro	2003	-	-	-	-	-	-	-	-	-	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.