TBDReaMDB: INH: Rv1908c

Rv1908c

More about Rv1908c on TBDB.org

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Rv1908c: Codons 100 to 119: 12 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Rouse et al MM 1996	CGG/CTG	311	104	Arg/Leu	1996	-	-	-	-	>500	N.S.	n/a	100 fold reduction in peroxidase activity	-	-
Gagneux S PLOS Path 2006	CGG/CAG	311	104	Arg/Gln	-	-	-	-	-	-	-	-	-	-	-
Gagneux S PLOS Path 2006	GCG/GTG	317	106	Ala/Val	-	-	-	-	-	-	-	-	-	-	-
Gagneux S PLOS Path 2006	TGG/CGG or TGG/AGG	319	107	Trp/Arg	-	-	-	-	-	-	-	-	-	-	-
Baker LV AAC 2005	TGG/TGA	321	107	Trp/STOP	1998	United Kingdom	Directed Oligonucleotide array, Sequencing	Whole gene	H,HS,HE,HSE,MDR	ratio>=4	Resistance ratio method	202/378	1/0	ahpC-30T	-
Rouse et al MM 1996	CAC/GAC	322	108	His/Asp	1996	-	-	-	-	-	N.S	n/a	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	CAC/GAA or CAC/GAG	322,324	108	His/Glu	-	-	-	-	-	-	-	-	-	-	-
Rouse DA AAC 1995	CAC/CAG	324	108	His/Gln	1995	USA, South Korea	PCR-SSCP, Sequencing	Whole gene	H	50	Absolute concentration method	26/26	1/0	-	-
Gagneux S PLOS Path 2006	GCT/GTT	326	109	Ala/Val	-	-	-	-	-	-	-	-	-	-	-
Wei CJ AAC 2003	GCC/GTC	329	110	Ala/Val	2003	-	-	-	H	-	-	-	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	del	?	113	Frameshift?	-	-	-	-	-	-	-	-	-	-	-
Lavender C AAC 2005	GAC/GCC	350	117	Asp/Ala	2001-2003	Australia	Sequencing	Whole gene	HR	0.4 ug/ml I	BACTEC	52/104	1/0	-	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.