Rv0129c: fbpCRv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1483: mabARv1484: inhARv1854c: ndhRv1592cRv1772Rv1908c: katG1909c: furARv2242: srm R homologRv2243: fabDRv2245: kasARv2247: accD6Rv2427A: oxyRRv2428: ahpCRv2846c: efpARv3139: fadE24Rv3566c: nhoARv3795: embB

Rv1908c

More about Rv1908c on    TBDB.org

More about Rv1908c on    TubercuList

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Display high confidence mutations only
Rv1908c: Codons 0 to 19: 9 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Gagneux S PLOS Path 2006 GTG/TTG or GTG/CTG 1 1 Val/Leu - - - - - - - - - - -
Heym B MolMicro 1995 GTG/GCG 2 1 Val/Ala 1995 Russia PCR-SSCP, Sequencing Whole gene MDR 1 Proportion method 34/37 1/0 - -
Cockerill FR JID 1995 CCC/TCC 4 2 Pro/Ser 1995 USA, Japan Sequencing Whole gene - 0.12 Proportion method 40071 1/0 Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr, Tyr337Phe -
Siddiqi N AAC 2002 del C 30 10 TRUNC 26aa 1995-1998 India Sequencing nt 3-239 & 1187-1600 H,HRO,HR,HROS 10ug/ml R, 1ug/ml I, 2ug/ml O 2ug/ml S Proportion method 74/126 6/0 R463L KatG, S95T gyrA, H526R rpo, H526Y rpo, D516V rpo, S531L rpo, D94A gyrA, K121K rpsL -
Cockerill FR JID 1995 del 8bp - 10 Frameshift 1995 USA Sequencing Whole gene H >32ug/ml Proportion method 40071 1/0 Ala424Val and Ala550Asp in katG. -
Siddiqi N AAC 2002 ACC/GCC 31 11 Thr/Ala 1995-1998 India Sequencing 3-239,1187-1600 H,R 10ug/ml R, 1ug/ml I Proportion method 74/126 1/0 R463L KatG, D516G rpo -
Siddiqi N AAC 2002 ACC/CCC 34 12 Thr/Pro 1995-1998 India Sequencing nt 3-239 1187-1600 H 1ug/ml I Proportion method 74/126 1/0 R463L KatG -
Cockerill FR JID 1995 AGC/AAC 50 17 Ser/Asn 1995 USA Sequencing Whole gene H 0.12-1ug/ml Proportion method 40071 - Gly19Asp, Gln224Glu, Ala243Ser, Ala550Asp -
Cockerill FR JID 1995 GGC/GAC 56 19 Gly/Asp 1995 USA Sequencing Whole gene H 0.12ug/ml Proportion method 40071 0/1 Pro2Ser, Ser17Asn, Gln224Glu, Ala243Ser, Ala550Asp -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator