Rv0129c: fbpCRv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1483: mabARv1484: inhARv1854c: ndhRv1592cRv1772Rv1908c: katG1909c: furARv2242: srm R homologRv2243: fabDRv2245: kasARv2247: accD6Rv2427A: oxyRRv2428: ahpCRv2846c: efpARv3139: fadE24Rv3566c: nhoARv3795: embB

Rv1908c

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Display high confidence mutations only
Rv1908c: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Baker LV AAC 2005 ins C -1 - Frameshift 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 1/0 CCC-CCG substitution at nt 723, Pro-Pro -
Gagneux S PLOS Path 2006 GTG/TTG or GTG/CTG 1 1 Val/Leu - - - - - - - - - - -
Heym B MolMicro 1995 GTG/GCG 2 1 Val/Ala 1995 Russia PCR-SSCP, Sequencing Whole gene MDR 1 Proportion method 34/37 1/0 - -
Cockerill FR JID 1995 CCC/TCC 4 2 Pro/Ser 1995 USA, Japan Sequencing Whole gene - 0.12 Proportion method 40071 1/0 Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr, Tyr337Phe -
Siddiqi N AAC 2002 del C 30 10 TRUNC 26aa 1995-1998 India Sequencing nt 3-239 & 1187-1600 H,HRO,HR,HROS 10ug/ml R, 1ug/ml I, 2ug/ml O 2ug/ml S Proportion method 74/126 6/0 R463L KatG, S95T gyrA, H526R rpo, H526Y rpo, D516V rpo, S531L rpo, D94A gyrA, K121K rpsL -
Cockerill FR JID 1995 del 8bp - 10 Frameshift 1995 USA Sequencing Whole gene H >32ug/ml Proportion method 40071 1/0 Ala424Val and Ala550Asp in katG. -
Siddiqi N AAC 2002 ACC/GCC 31 11 Thr/Ala 1995-1998 India Sequencing 3-239,1187-1600 H,R 10ug/ml R, 1ug/ml I Proportion method 74/126 1/0 R463L KatG, D516G rpo -
Siddiqi N AAC 2002 ACC/CCC 34 12 Thr/Pro 1995-1998 India Sequencing nt 3-239 1187-1600 H 1ug/ml I Proportion method 74/126 1/0 R463L KatG -
Cockerill FR JID 1995 AGC/AAC 50 17 Ser/Asn 1995 USA Sequencing Whole gene H 0.12-1ug/ml Proportion method 40071 - Gly19Asp, Gln224Glu, Ala243Ser, Ala550Asp -
Cockerill FR JID 1995 GGC/GAC 56 19 Gly/Asp 1995 USA Sequencing Whole gene H 0.12ug/ml Proportion method 40071 0/1 Pro2Ser, Ser17Asn, Gln224Glu, Ala243Ser, Ala550Asp -
Ramaswamy SV J Med Micro 2004 del 85-1059 29-353 Truncation 1996-1998 Mexico Directed Oligonucleotide array, Sequencing codon 228-357 H,R,E >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E Proportion method 37/50 1/0 "nt 1238; T-C rrs " -
Siddiqi N AAC 2002 ins A 98 33 Truncation 1995-1998 India Sequencing nt 3-239 & 1187-1600 HR,HRS 10ug/ml R, 1ug/ml I Proportion method 74/126 4/0 S531W rpo, H526L rpo, R463L KatG, D516G rpo, H526R rpo -
Siddiqi N AAC 2002 AAC/GAC 103 35 Asn/Asp 2002 India Sequencing. 237bp + 414bp fragments I,IRSO >1ug/ml Proportion method 74/126 2/0 "One mutant at katG Arg463Leu; both mutant at rpoB Asp516Val." -
Siddiqi N AAC 2002 del G 109 37 TRUNC 45aa 1995 India Sequencing nt 3-239 & 1187-1600 HRO,HR 10ug/ml R, 1ug/ml I 2ug/ml O Proportion method 74/126 2/0 S531W rpo, S95T gyrA, L511L H526R rpo -
Secondary Publication: Hazbon MH AAC 2006 TGG/TGA 114 38 Trp/STOP - - - - - - - - - - -
Sekigushi J JCM 2007 CTG/CAG 143 48 Leu/Gln 2007 Japan Sequencing Whole gene - - Proportion method, BACTEC 38/138 1/0 -15C/T upstream of mabA -
Baker LV AAC 2005 del A 149 50 Frameshift 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 1/0 ahpC-34A -
Pretorius GS AAC 1995 del CCGTCGCTGACC 157-168 52-57 del Ala Val Ala Asp Pro 1995 USA PCR-SSCP, Sequencing 1-221, 202-338, 319-558, 541-741, 722-942, 923-1140, 1120-1342, 1323-1526, 1507-1718, 1699-1915, 1896-2115, 2096-2310 HR 1.0 ug/ml Proportion method 39/69 1/0 - -
Siddiqi N AAC 2002 GCG/ACG 181 61 Ala/Thr 1995-1998 India Sequencing nt 3-239 & 1187-1600 HRO 10ug/ml R, 1ug/ml I, 2ug/ml O Proportion method 74/126 1/0 R463L KatG, S95T gyrA, S531L rpo -
Siddiqi N AAC 2002 ins C 185 62 Truncation 1995-1998 India Sequencing nt 3-239 & 1187-1600 HRS,HO,HR 10ug/ml R, 1ug/ml I 2ug/ml O Proportion method 74/126 3/0 S531W rpo, K121K rpsL, S95T gyrA,H526R rpo -
Rouse DA AAC 1995 GAC/GAA 189 63 Asp/Glu 1995 USA, South Korea PCR-SSCP, Sequencing Whole gene H 50ug/ml Absolute concentration method. 26/26 1/0 - -
Marttila HJ AAC 1996 ins CCCC 195 65 Frameshift 1989-1995 Finland Sequencing Whole gene H 1ug/ml Disk elution method 54/56 1/0 - -
Cockerill FR JID 1995 GCC/ACC 193 65 Ala/Thr 1995 USA PCR, RFLP, Sequencing. Whole gene H 0.25ug/ml Proportion method 40071 0/1 Ala66Pro and others in katG. -
Cockerill FR JID 1995 GCG/CCG 196 66 Ala/Pro 1995 USA Sequencing Whole gene H 0.25ug/ml Proportion method 40071 0/1 Ala65Thr, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr, Tyr337Phe -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ATC/AAC 212 71 Ile/Asn - - - - - - - - - - -
Chan RCY JAC 2007 GAC/GGC - 72 Asp/Gly 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Secondary Publication: Hazbon MH AAC 2006 GAC/AAC 214 72 Asp/Lys - - - - - - - - - - -
Siddiqi N AAC 2002 GAC/AAC ? 73 Asp/Asn 1995 India Sequencing nt 3-239 & 1187-1600 H 1ug/ml I Proportion method 74/126 1/0 R463L KatG -
Chan RCY JAC 2007 GAC/TAC 220 74 Asp/Tyr 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Chan RCY JAC 2007 GAC/GGC 221 74 Asp/Gly 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Chan RCY JAC 2007 ATG/ATA 252 84 Met/Ile 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Gagneux S PLOS Path 2006 ACC/CCC 253 85 Thr/Pro - - - - - - - - - - -
Marttila HJ AAC 1998 CAG/CGG 263 88 Gln/Arg - - - - - - - - - - -
Cockerill FR JID 1995 TGG/TGA 270 90 Trp/STOP 1995 USA, Japan Sequencing Whole gene - ">32; catalase 5 mm" Proportion method 40071 1/0 none -
Ramaswamy SV AAC 2003 TGG/CGG 271 91 Trp/Arg - USA, Mexico Sequencing - - 2 "BACTEC radiometric method; E-test" 38/121 1/0 D3G (srmR homolog) -
Gagneux S PLOS Path 2006 GAC/GGC 281 94 Asp/Gly - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GAC/GCC 281 94 Asp/Ala - - - - - - - - - - -
Chan RCY JAC 2007 GGC/TGC ? 96 Gly/Cys 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GGG/GAG 296 99 Gly/Glu - - - - - - - - - - -
Rouse et al MM 1996 CGG/CTG 311 104 Arg/Leu 1996 - - - - >500 N.S. n/a 100 fold reduction in peroxidase activity - -
Gagneux S PLOS Path 2006 CGG/CAG 311 104 Arg/Gln - - - - - - - - - - -
Gagneux S PLOS Path 2006 GCG/GTG 317 106 Ala/Val - - - - - - - - - - -
Gagneux S PLOS Path 2006 TGG/CGG or TGG/AGG 319 107 Trp/Arg - - - - - - - - - - -
Baker LV AAC 2005 TGG/TGA 321 107 Trp/STOP 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 1/0 ahpC-30T -
Rouse et al MM 1996 CAC/GAC 322 108 His/Asp 1996 - - - - - N.S n/a - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CAC/GAA or CAC/GAG 322,324 108 His/Glu - - - - - - - - - - -
Rouse DA AAC 1995 CAC/CAG 324 108 His/Gln 1995 USA, South Korea PCR-SSCP, Sequencing Whole gene H 50 Absolute concentration method 26/26 1/0 - -
Gagneux S PLOS Path 2006 GCT/GTT 326 109 Ala/Val - - - - - - - - - - -
Wei CJ AAC 2003 GCC/GTC 329 110 Ala/Val 2003 - - - H - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del ? 113 Frameshift? - - - - - - - - - - -
Lavender C AAC 2005 GAC/GCC 350 117 Asp/Ala 2001-2003 Australia Sequencing Whole gene HR 0.4 ug/ml I BACTEC 52/104 1/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del ? 120 Frameshift? - - - - - - - - - - -
Heym B MolMicro 1995 del 358-369 120-123 del 1995 Yugoslavia PCR-SSCP, Sequencing Whole gene H - Proportion method 34/37 2/0 - -
Gagneux S PLOS Path 2006 GGC/TGC 361 121 Gly/Cys - - - - - - - - - - -
Marttila HJ AAC 1998 GGC/GTC 362 121 Gly/Val 1993-1995 Russia Sequencing. Whole gene HR N/A Proportion method 24/27 1/0 Asp516Val in rpoB -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del ? 122 Frameshift? - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del ? 123 Frameshift? - - - - - - - - - - -
Ramaswamy SV AAC 2003 ins G 372 124 Frameshift - USA, Mexico Sequencing - - >256 BACTEC 460, E-test 38/121 1/0 G-9A (oxyR-ahpC) -
Chan RCY JAC 2007 GGC/TGC 373 125 Gly/Cys 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Heym B MolMicro 1995 ins CAT 373-375 125 ins His 1995 Yugoslavia PCR-SSCP, Sequencing Whole gene H - Proportion method 34/37 1/0 - -
Cockerill FR JID 1995 ATG/ATT, ATG/ATC or ATG/ATA 378 126 Met/Ile 1995 USA, Japan Sequencing Whole gene - ".025; catalase 14 mm" Proportion method 40071 1/0 "A65T; A66P; A243S; N258S; A264T; Y337F" -
Chan RCY JAC 2007 CAG/CCG 380 127 Gln/Pro 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Fang Z JCM 1999 CGG/CCG 384 128 Arg/Pro 1990-1997 United Kingdom PCR-SSCP, Sequencing 2268-2288&2595-2615, 2781-2801&3115-3135, 3366-3386& 3633-3653, 3661-3681& 3973-3993 H,E,R,P,Rifa,Cip,Ami,S,Proth - BACTEC 460 10/715 1/0 Leu511Pro rpoB -
Hazbon MH AAC 2006 AAC/CAC 412 138 Asn/His 2006 USA, Spain HP asay, molecular beacon assay, Sequencing - H 0.2ug/ml proportion method, 0.1 for BACTEC methods Proportion method, BACTEC MGIT 960, BACTEC 460 403/1111 1/0 - -
Hazbon MH AAC 2006 AAC/GAC 412 138 Asn/Asp 2006 USA, Spain HP asay, molecular beacon assay, Sequencing - H 0.2ug/ml proportion method, 0.1 for BACTEC methods Proportion method, BACTEC MGIT 960, BACTEC 460 403/1111 2/0 - -
Hazbon MH AAC 2006 AAC/AGC 413 138 Asn/Ser 2006 USA, Spain HP asay, molecular beacon assay, Sequencing - H 0.2ug/ml proportion method, 0.1 for BACTEC methods Proportion method, BACTEC MGIT 960, BACTEC 460 403/1111 1/0 - -
Morlock GP AAC 2003 AAC/ACC 413 138 Asn/Thr 2003 USA, Russia, Brazil Sequencing Whole gene H >32ug/ml Microplate alamar blue assay method 17/41 1/0 - -
Wei CJ AAC 2003 GCC/CCC 415 139 Ala/Pro 2003 - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/GCC? 418-419? 140 Ser/Ala - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/AAC 419 140 Ser/Asn 2006 USA, Spain HP asay, molecular beacon assay, Sequencing - - 0.2ug/ml proportion method, 0.1 for BACTEC methods Proportion method, BACTEC MGIT 960, BACTEC 460 403/1111 9/0 - -
Secondary Publication: Hazbon MH AAC 2006 AGC/GGC 418 140 Ser/Gly - - - - - - - - - - -
Hai Hua Lin TubercRespirDis 2007 AGC/AGA 420 140 Ser/Arg 2004 South Korea Sequencing Whole gene MDR N.S. N.S 29/29 1/0 katG N238K -
Sekigushi J JCM 2007 TTG/TTC 423 141 Leu/Phe 2007 Japan, Poland Sequencing Whole gene - - Proportionmethod, BACTEC MGIT 960 38/138 2/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GAC/GCC 425 142 Asp/Ala - - - - - - - - - - -
Gagneux S PLOS Path 2006 AAG/ACG 428 143 Lys/Thr - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CTG/GCG 443 148 Leu/Ala - - - - - - - - - - -
Rouse et al MM 1996 CTG/CGG 443 148 Leu/Arg 1996 - - - - - N.S. n/a - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CCG/GCG?? See Note See Note 150 Leu/Ala Error? See Note - - - - - - - - - - -
Marttila HJ AAC 1998 TAC/TCC 464 155 Tyr/Ser 1993-1995 Russia Sequencing. Whole gene HRSK 1 ug/ml I, 5 ug/ml R Proportionmethod 24/27 1/0 Arg463Leu katG, Ser 531Leu rpoB -
Gagneux S PLOS Path 2006 TAC/TGC 464 155 Tyr/Cys 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 3 -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TCA/TTA 479 160 Ser/Leu - - - - - - - - - - -
Gagneux S PLOS Path 2006 GCG/ACG 484 162 Ala/Thr - - - - - - - - - - -
Cockerill FR JID 1995 GGC/GCC 506 169 Gly/Ala 1995 USA Sequencing. Whole gene H 1ug/ml Proportion method 40071 1/0 Pro2Ser, Ser17Asn, Met126Ile, Gln224Glu, Ala264Val, Ala281Val, Try337Cys, Arg463Leu -
Secondary Publication: Hazbon MH AAC 2006 GCG/ACG 514 172 Ala/Thr 2006 USA, Spain HP asay, molecular beacon assay, Sequencing - H 0.2ug/ml proportion method, 0.1 for BACTEC methods Agar Proportion method, BACTEC MGIT 960, BACTEC 460 403/1111 2/0 - -
Chan RCY JAC 2007 GCG/GTG 515 172 Ala/Val 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Chan RCY JAC 2007 ATG/ATA 528 176 Met/Ile 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 3 -
Secondary Publication: Hazbon MH AAC 2006 ACG/AAG 539 180 Thr/Lys - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ACG/??? See Note 180 Thr/Cys - - - - - - - - - - -
Chan RCY JAC 2007 GGC/GTC 557 186 Gly/Val 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Chan RCY JAC 2007 GGC/CAC 556-557 186 Gly/His 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Baker LV AAC 2005 TGG/CGG 571 191 Trp/Arg 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 1/0 - -
Chan RCY JAC 2007 del G 572 191 Frameshift 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Morlock GP AAC 2003 G/A 583 195 Glu/Lys 2003 USA Sequencing Whole gene Eth 1 Microplate alamar blue assay 17/41 0/1 nt 280 T/G inh ORF -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TGG/TGA 594 198 Trp/STOP - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AAG/TAG 598 200 Lys/STOP - - - - - - - - - - -
Abe C JCM 2008 - - 204 Trp/Arg Published in 2008 Japan Sequencing Whole gene H - MGIT 960 96/96 1/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins ? 217 Frameshift? - - - - - - - - - - -
Chan RCY JAC 2007 AAC/AAA 654 218 Asn/Lys 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Cockerill FR JID 1995 CAG/GAG 670 224 Gln/Glu 1995 USA, Japan Sequencing Whole gene - "1; catalase 8 mm" Proportionmethod - 1/0 Pro2Ser, Ser17Asn, Met126Ile, Gly169Ala, Ala264Val, Ala281Val, Try337Cys, Arg463Leu -
Cockerill FR JID 1995 CAG/GAG 670 224 Gln/Glu 1995 USA Sequencing Whole gene H <0.12-1ug/ml Proportion method - 39815 Ala424Glu, Pro429Ser -
Ghiladi RA J Am Chem Soc 2005 TAC/TTC 686 229 Tyr/Phe - - - - - - - - - - -
Chan RCY JAC 2007 GTG/GCG 689 230 Val/Ala 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Baker LV AAC 2005 GGG/GAG 701 234 Gly/Glu 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 1/0 - -
Chan RCY JAC 2007 GGG/AGG 700 234 Gly/Arg 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Chan RCY JAC 2007 AAC/ACC 707 236 Asn/Thr 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Hai Hua Lin TubercRespirDis 2007 AAC/AAG 714 238 Asn/Lys 2004 South Korea Sequencing Whole gene MDR N.S. N.S 29/29 1/0 katG S140R -
Baker LV AAC 2005 CCC/CCG 723 241 Pro/Pro 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 2/0 - -
Cockerill FR JID 1995 GCC/TCC 727 243 Ala/Ser 1995 USA, Japan Sequencing Whole gene - "0.12; catalase 28mm" "Middlebrook 7H11 agar; 1% Proportion method" - 1/0 Pro2Ser, Ser17Asn, Gly19Asp, Gln224Glu, Ala550Asp -
Ramaswamy SV J Med Micro 2004 CGC/TGC 745 249 Arg/Cys 1996-1998 Mexico Directed Oligonucleotide array, Sequencing codon 228-357 HRSE >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E Proportion method 37/50 2/0 His445Tyr rpoB, Lys43Arg rpsL, Met306Ile embB -
Gagneux S PLOS Path 2006 ACG/ATG 752 251 Thr/Met - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TTT/CTT 754 252 Phe/Leu - - - - - - - - - - -
Sekigushi J JCM 2007 ATG/ACG 770 257 Met/Thr 2007 Japan, Poland Multiplex Sequencing Whole gene - - Middlebrook 7H10 agar medium method Ogawa egg based medium method, Rapid broth method(BACTEC) 38/138 1/0 R463L V780P katG, -15C/T upstream of mabA -
Lavender C AAC 2005 ATG/ATT 771 257 Met/Ile 2001-2003 Australia Multiplex allele specific PCR Assay Whole gene HR 0.1ug/ml I, 1ug/ml R BACTEC MGIT960 52/104 1/0 - -
Cockerill FR JID 1995 AAC/AGC 773 258 Asn/Ser 1995 USA Sequencing. Whole gene H 0.25ug/ml Proportion method - 0/1 Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Ala264Thr, Tyr337Phe -
Rouse DA AAC 1995 ACA/AGA 785 262 Thr/Arg 1995 USA, South Korea PCR-SSCP, Sequencing Whole gene H 1 ug/ml Absolute concentration method 26/26 1/0 - -
Cockerill FR JID 1995 GCG/ACG 790 264 Ala/Thr 1995 USA, Japan Sequencing Whole gene - "0.25; catalase 14mm" "Middlebrook 7H11 agar; 1% Proportion method" - 1/0 Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Tyr337Phe -
Chan RCY JAC 2007 del G - 268 Frameshift 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Pretorius GS AAC 1995 ACC/GCC 820 275 Thr/Ala 1995 South Africa, Switzerland PCR-SSCP, Sequencing Whole gene? HR,HRSEEryB 10 & >2.5 ug/ml Agar dilution method 39/69 2/0 - -
Heym B MolMicro 1995 ACC/CCC 823 275 Thr/Pro 1995 France PCR-SSCP, Sequencing Whole gene HMDR > 10 ug/ml Proportion method 34/37 1/0 - -
Ramaswamy SV J Med Micro 2004 ACC/TCC 823 275 Thr/Ser 1996-1998 Mexico Directed Oligonucleotide array, Sequencing codon 228-357 HR >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E Proportion method 37/50 1/0 His445Asp rpoB, -
Morlock GP AAC 2003 GGC/GAC 836 279 Gly/Asp 2003 Brazil Sequencing fragment encompassing codons 249 to 342 HEth >32 I, >200 Eth Microplate alamar blue assay 17/41 1/0 D55/A ethA,L44L inhA ORF, C(-15)T inhA regulator
Gagneux S PLOS Path 2006 CCG/CAT or CCG/CAC 839-840 280 Pro/His - - - - - - - - - - -
Cockerill FR JID 1995 GCC/GTC 842 281 Ala/Val 1995 USA Sequencing Whole gene H 1ug/ml Proportion method - 1/0 Pro2Ser, Ser17Asn, Met126Ile, Gly169Ala, Gln224Glu, Ala264Val, Try337Cys, Arg463Leu -
Abe C JCM 2008 GGC/GAC 854 285 Gly/Asp Published in 2008 Japan Sequencing Whole gene H - MGIT 960 96/96 1/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins ? 289 Frameshift? - - - - - - - - - - -
Chan RCY JAC 2007 GAG/GAC 867 289 Glu/Asp 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Fang Z JCM 1999 GCT/CCT 871 291 Ala/Pro 1990-1997 United Kingdom PCR-SSCP, Sequencing - HR - BACTEC 10/715 1/0 His 526Tyr rpoB -
Sekigushi J JCM 2007 CAG/CCG 884 295 Gln/Pro 2007 Poland Sequencing Whole gene - - Proportion method, BACTEC 38/138 1/0 - -
Sekigushi J JCM 2007 GGC/GTC 890 297 Gly/Val 2007 Poland Sequencing Whole gene - - Proportion method, BACTEC 38/138 1/0 - -
Chan RCY JAC 2007 GGC/TGC 895 299 Gly/Cys 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 1 -
Huang WL JCM 2009 GGC/GCC 896 299 Gly/Ala 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Lee ASG AAC 1999 TGG/TAA or TGG/TAG or TGG/TGA - 300 Trp/STOP 1994-1996 Singapore Sequencing Whole gene H 0.1 ug/ml BACTEC 460 160/192 - - -
Marttila HJ AAC 1996 TGG/GGG 898 300 Trp/Gly 1989-1995 Finland Sequencing Whole gene H 1 ug/ml Disk elution method 54/56 1/0 - -
Gagneux S PLOS Path 2006 ins T 901-902 301 Frameshift - - - - - - - - - - -
Cockerill FR JID 1995 AGC/AGG 906 302 Ser/Arg 1995 USA Sequencing Whole gene H 8ug/ml Proportion method 40071 1/0 Ser315Thr and Arg463Leu in katG. -
Bolotin S JAC 2009 TAT/TCT 911 304 Tyr/Ser 1999-2001 Canada Sequencing codon 250-500 H, HR - MGIT 960 154/504 1/0 - -
Bostanabad SZ Tuberk Torak 2007 GGC/GCC 913 305 Gly/Ala 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 3/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GGA/CGA 919 307 Gly/Arg 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 1/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GGA/GCA 920 307 Gly/Ala 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Ramaswamy SV J Med Micro 2004 GGA/GAA 920 307 Gly/Glu 1996-1998 Mexico Directed Oligonucleotide array, Sequencing codon 228-357 HRSE >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E Proportion method 37/50 1/0 Ser450Leu rpoB, -
Khadka DK Southest Asian J Trop Med Public Health 2007 ACC/CCC 922 308 Thr/Pro 2007 Bangkok PCR-SSCP, Sequencing 894 bp fragment encompassing codons 254 to 549 HRSEO - - 29/30 1/0 Arg463Leu katG, C(-15)T inhA -
Bostanabad SZ Tuberk Torak 2007 GGT/GTT 926 309 Gly/Cys 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GGT/GCT 926 309 Gly/Ser 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Kim SY Diagn Micro Inf Dis 2003 GGT/GAT 926 309 Gly/Asp 200-2002 South Korea PCR-SSCP, Sequencing 210 bp fragment spanning codon 315 HR 0.2 ug/ml I 40 ug/ml R Proportion method 71/97 2/0 inhA Ribosomal binding site C/T -
Bostanabad SZ Tuberk Torak 2007 GGT/GTC 926-927 309 Gly/Phe 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Huang WL JCM 2009 del A 928-929 310 Frameshift 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Bostanabad SZ Tuberk Torak 2007 GAC/TAC 931 311 Asp/Tyr 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GAC/TTC 931-932 311 Asp/Phe 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Chan RCY JAC 2007 GAC/GGC 932 311 Asp/Gly 2007 Hong Kong PCR-SSCP, Sequencing 703 bp fragment HEP 1ug/ml I, 4ug/ml E, 100ug/ml P Absolute concentration method, BACTEC MGIT 960 241/302 1/0 574Ser/Leu rpoB -
Zenteno-Cuevas R MemInstOswaldCruz 2009 GAC/GAG 933 311 Asp/Glu 2007 Mexico Sequencing codon 240-390 of katG HREZ N.S. BACTEC 460 17/25 1/0 katG S315T -
Bostanabad SZ Tuberk Torak 2007 ACC/AAC 941 314 Ser/Asn 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 ACC/ACG 941-942 314 Ser/Thr 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Haas WA AAC 1997 AGC/CGC 943 315 Ser/Arg 1997 South Africa PCR-RFLP 894 bp central fragment of katG? H - - 124/212 1/0 - -
Marttila HJ AAC 1996 AGC/CTA 943 315 Ser/Leu 1989-1995 Finland Sequencing Whole gene HS >1ug/ml Disk elution method. 17/19 1/0 katG Pro501Ala. -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/GGC 943 315 Ser/Gly - - - - - - - - - - -
Musser JM JID 1996 AGC/ACC 944 315 Ser/Thr - - - - - - - - - - -
Haas WA AAC 1997 AGC/ATC 944 315 Ser/Ile 1997 Sierra Leone, Lesotho PCR-RFLP 892 bp central fragment HRSEth,H - - 124/212 4/0 -
Haas WA AAC 1997 AGC/AAC 944 315 Ser/Asn 1997 Free state, Gauteng, Sierra leone PCR-RFLP 890 bp fragment H,HRE,HR - - 124/212 9/0 -
Heym B MolMicro 1995 AGC/ACC 944 315 Ser/Thr 1995 Mali Ivory coast, France PCR-SSCP, Sequencing Whole gene H 1 in 4 and >5 in 1 Proportional method 34/37 5/0 -
Marttila HJ AAC 1996 AGC/ACA 944-945 315 Ser/Thr 1989-1995 Finland Sequencing Whole gene HS,HRS 1 ug/ml for I Disk elution method. 54/56 2/0 nt1501G/C katG in one
Gagneux S PLOS Path 2006 AGC/ACG 944-945 315 Ser/Thr - - - - - - - - - - -
Lipin MY CMI 2007 AGC/AGA 945 315 Ser/Arg 1998-2001 Russia Sequencing nt 872-1568 HRS 1 ug/ml I, 5 ug/ml S, 20ug/ml R Absolute concentration method 217/217 2/0 335 /GTC katG in one
Secondary Publication: Hazbon MH AAC 2006 AGC/AGG 945 315 Ser/Arg - - - - - - - - - - -
Bostanabad SZ Tuberk Torak 2007 GGC/AGC 946 316 Gly/Ser 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 18/0 Most had 1-4 other katG mutations (most often in codon 315). -
Secondary Publication: Hazbon MH AAC 2006 GGC/GAC 947 316 Gly/Asp - - - - - - - - - - -
Chan RCY JAC 2007 ATC/CTC 949 317 Ile/Leu 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 2 -
Zenteno-Cuevas R MemInstOswaldCruz 2009 GAG/GTA 953-954 318 Gly/Val 2007 Mexico Sequencing codon 240-390 of katG HRSEZ N.S. BACTEC 460 17/25 1/0 katG S315T -
Chan RCY JAC 2007 TGG/CGG 961 321 Trp/Arg 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 3 -
Bostanabad SZ Tuberk Torak 2007 TGG/TAG 961 321 Trp/STOP 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 TGG/TTG 962 321 Trp/Leu 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 TGG/TCC 962-963 321 Trp/Ser 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 1/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 TGG/TGT 963 321 Trp/Cys 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 1/0 Most had 1-4 other katG mutations (most often in codon 315). -
No publication listed ACC/CCC 970 324 Thr/Pro - - - - - - - - - - -
Musser JM JID 1996 TGG/GGG 982 328 Trp/Gly 1996 - Sequencing Whole gene HR >=1ug/ml for I Proportion method 34/46 1/0 - -
Haas WA AAC 1997 TGG/TTG 983 328 Trp/Leu 1997 Free state, Lesotho, Eastern Cape, Natal, Swaziland, Gauteng PCR-RFLP 894 bp central fragment of katG H - - 124/212 1/0 - -
Boonaiam S CMI 2009 TGG/TCG 984 328 Trp/Ser 2005-2006 Thailand Sequencing Whole gene MDR >=1ug/ml for I Disk elution method 160/170 1/0 - -
Haas WA AAC 1997 TGG/TGC 984 328 Trp/Cys 1997 Free state, Lesotho, Eastern Cape, Natal, Swaziland, Gauteng PCR-RFLP 894 bp central fragment of katG H - - 124/212 1/0 - -
Bostanabad SZ Tuberk Torak 2007 TGG/TGT 984 328 Trp/Cys 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 4/0 Most had 1-4 other katG mutations (most often in codon 315). -
Zenteno-Cuevas R MemInstOswaldCruz 2009 AGT/TGT 991 331 Ser/Cys 2007 Mexico Sequencing codon 240-390 of katG HRS N.S. BACTEC 460 17/25 1/0 katG S315T -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 - See Note 334 Ile/Thr Error - - - - - - - - - - -
Rouse DA AAC 1995 ATC/ACC 1004 335 Ile/Thr - - - - - - - - - - -
Lipin MY CMI 2007 ATC/GTC 1003 335 Ile/Val 1998-2001 Russia Sequencing nt 872-1568 HRS 1 ug/ml I, 5 ug/ml S, 20ug/ml R Absolute concentration method 217/217 1/0 315 AGC/AGA katG -
Lee ASG AAC 1999 CTG/CGG 1007 336 Leu/Arg - - - - - - - - - - -
Cockerill FR JID 1995 TAC/TTC 1010 337 Tyr/Phe 1995 USA PCR, RFLP, Sequencing. Whole gene H 0.25ug/ml Proportion method - - Pro2Ser, Ala65Thr, Ala66Pro, Met126Ile, Ala243Ser, Asn258Ser, Ala264Thr -
Cockerill FR JID 1995 TAC/TGC 1010 337 Tyr/Cys 1995 USA PCR, RFLP, Sequencing. Whole gene H 1ug/ml Proportion method - 1/0 Arg429Leu, Trp505Arg, Met609Ile -
Morlock GP AAC 2003 TGG/TCG 1022 341 Trp/Ser 2003 Brazil Sequencing fragment encompassing codons 249 to 342 HEth 5o Eth, >32 I Microplate alamar blue assay 17/41 1/0 4463S ethA, C(-15)T inhA regulator -
Gagneux S PLOS Path 2006 AAG/ACG 1034 345 Lys/Thr - - - - - - - - - - -
Chan RCY JAC 2007 del G - 346 Frameshift 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 2 -
Rouse et al MM 1996 GCT/ACT 1048 350 Ala/Thr 1996 - - - - - N.S. n/a - - -
Rouse DA AAC 1995 GCT/TCT 1048 350 Ala/Ser 1995 - PCR SSCP Whole gene H 1 ug/ml Absolute concentration method 26/26 1/0 - -
Boonaiam S CMI 2009 CAA/TAA 1054 352 Gln/STOP 2005-2006 Thailand Sequencing Whole gene MDR >=1ug/ml for I Disk elution method 160/170 1/0 - -
Bostanabad SZ Tuberk Torak 2007 GAC/CAC 1069 357 Asp/His 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 1/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bostanabad SZ Tuberk Torak 2007 GAC/AAC 1069 357 Asp/Asn 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 1/0 Most had 1-4 other katG mutations (most often in codon 315). -
Huang WL JCM 2009 GCC/GAC 1082 361 Ala/Asp 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Huang WL JCM 2009 del T 1091 364 Frameshift 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Huang WL JCM 2009 CTG/CCG 1133 378 Leu/Pro 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Huang WL JCM 2009 GCC/GTC 1136 379 Ala/Val 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Chan RCY JAC 2007 ACT/ATT 1139 380 Thr/Ile 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 2 -
Rouse et al MM 1996 GAC/GGC 1142 381 Asp/Gly 1996 - - - - - N.S. n/a - - -
Gagneux S PLOS Path 2006 CTG/CGG 1151 384 Leu/Arg - - - - - - - - - - -
Chan RCY JAC 2007 ACT/ATT 1169 390 Thr/Ile 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 2 -
Sekigushi J JCM 2007 ins CTA 1170 390 ins Leu 2007 Japan Sequencing Whole gene - - Proportion method, BACTEC 38/138 2/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ATC/AAC 1178 393 Ile/Asn - - - - - - - - - - -
Gagneux S PLOS Path 2006 ACG/GCG 1180 394 Thr/Ala - - - - - - - - - - -
Secondary Publication: Hazbon MH AAC 2006 TGG/TAG 1191 397 Trp/STOP - - - - - - - - - - -
Huang WL JCM 2009 del C - 401 Frameshift 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Pretorius GS AAC 1995 GCC/CGC 1225-1226 409 Ala/Arg 1995 South Africa PCR-SSCP, Sequencing - HRSEryB 2.5 ug/ml Agar dilution method 39/69 1/0 - -
Chan RCY JAC 2007 GCC/GAC 1226 409 Ala/Asp 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene N.S. - Absolute concentration method 250 241 2 -
Huang WL JCM 2009 TAC/CAC 1237 413 Tyr/His 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Bolotin S JAC 2009 AAG/AAC 1242 414 Lys/Asn 1999-2001 Canada Sequencing codon 250-500 H, HR - MGIT 960 154/504 1/0 - -
Ghiladi RA J Am Chem Soc 2005 CGA/CTA 1253 418 Arg/Leu - - - - - - - - - - -
Mo L Microb Drug Res 2004 CGA/CAA 1253 418 Arg/Gln - - - - - - - - - - -
Huang WL JCM 2009 GAC/CAC 1255 419 Asp/His 2007-2008 Taiwan Sequencing N.S. 242MDR N.S. MGIT 960 242/272 1/0 not mentiond -
Cockerill FR JID 1995 GCG/GAG 1271 424 Ala/Glu 1995 USA PCR, RFLP, Sequencing. Whole gene H <0.12ug/ml Proportion method - 0/1 Gln224Glu and Pro429Ser in katG. -
Cockerill FR JID 1995 GCG/GTG 1271 424 Ala/Val 1995 USA PCR, RFLP, Sequencing. Whole gene H >32ug/ml Proportion method - 1/0 8-bp deletion in codon 10 + Ala550Asp in katG. -
Cockerill FR JID 1995 CCG/TCG 1285 429 Pro/Ser 1995 USA PCR, RFLP, Sequencing. Whole gene H <0.12ug/ml Proportion method - 0/1 Gln224Glu and Ala 424Glu in katG. -
Ramaswamy SV AAC 2003 CAG/TAG 1300 434 Gln/STOP - USA, Mexico Sequencing - - >256 "BACTEC radiometric method (0.1ug/ml); E-test" 38/121 1/0 V163I (Rv0340) -
Zhang M J Clin Microb 2005 ins A 1329 438 Frameshift 2005 China "IS6110-based RFLP; Sequencing." Whole gene H - BACTEC MGIT 960 1/87 1/0 "Arg463Leu in katG; also 1 mutation in oxy-ahpC, and 1 in efpA." -
Hai Hua Lin TubercRespirDis 2007 GCG/ACG 1330 444 Ala/Thr 2004 South Korea Sequencing Whole gene MDR N.S. N.S 29/29 1/0 None -
Doustdar F MDR 2008 CTC/TTC 1345 449 Leu/Phe 2005-2006 Iran Sequencing 250bp around 315 and 212 bp around 463, 238bp of inhA and 293bp of ahpC H N.S. Proportion method 48/93 1/0 None -
Bostanabad SZ Tuberk Torak 2007 GAG/CGA 1360 454 Glu/Arg 2004-2005 Belarus PCR, Sequencing. 209-bp segment. H >1ug/ml Proportion method, BACTEC 42/42 2/0 Most had 1-4 other katG mutations (most often in codon 315). -
Bolotin S JAC 2009 AGC/ATC 1370 457 Ser/Ile 1999-2001 Canada Sequencing codon 250-500 H, HR - MGIT 960 154/504 1/0 - -
Hai Hua Lin TubercRespirDis 2007 ATC/ACC 1385 462 Ile/Thr 2004 South Korea Sequencing Whole gene MDR N.S. N.S 29/29 1/0 inhA -15 (C/T) -
Heym B MolMicro 1995 CGG/CTG 1389 463 Arg/Leu - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TGG/TGA 1431 477 Trp/STOP - - - - - - - - - - -
Baker LV AAC 2005 CGT/AGT 1450 484 Arg/Ser 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 1/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GGT/GTT 1454 485 Gly/Val - - - - - - - - - - -
Marttila HJ AAC 1996 G/C 1464 488 Lys/Asn 1989-1995 Finland PCR, Sequencing. Whole gene H >1ug/ml Disk elution method. 17/19 1/0 katG Gln295STOP -
Baker LV AAC 2005 CGC/TGC 1469 490 Arg/Cys 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 1/0 - -
Lavender C AAC 2005 GGC/TGC 1471 491 Gly/Cys 2001-2003 Australia Multiplex allele specific PCR assay Whole gene H 0.4 ug/ml BACTEC MGIT960 method 52/104 1/0 - -
Hai Hua Lin TubercRespirDis 2007 CAA/CAT 1506 502 Gln/His 2004 South Korea Sequencing Whole gene MDR N.S. N.S 29/29 1/0 inhA -15 (C/T) -
Abe C JCM 2008 TGG/TCG 1513 505 Trp/Ser Published in 2008 Japan Sequencing Whole gene H - MGIT 960 96/96 1/0 - -
Cockerill FR JID 1995 TGG/CGG 1513 505 Trp/Arg 1995 USA PCR, RFLP, Sequencing. Whole gene H >32ug/ml Proportion method - 1/0 Tyr337Phe, Arg429Leu, Met609Ile -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins ? ? 511 Frameshift - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins ? ? 513 Frameshift - - - - - - - - - - -
Zhang M J Clin Microb 2005 CGC/TGC 1543 515 Arg/Cys 2005 China Sequencing. Whole gene H 8ug/ml BACTEC MGIT 960 87/137 1/0 Arg463Leu in katG. -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ins ? ? 521 Frameshift - - - - - - - - - - -
Zhang M J Clin Microb 2005 ins 64bp 1559 521 Frameshift 2005 China Sequencing. Whole gene H >256ug/ml BACTEC MGIT 960 87/137 1/0 "Arg463Leu in katG; also 1 mutation in oxy-ahpC, and 1 in efpA." -
Marttila HJ AAC 1996 CAG/CCG 1574 525 Gln/Pro 1989-1995 Finland Sequencing Whole gene H 0.4 ug/ml for I disk elution method 54/56 1/0 - -
Ramaswamy SV AAC 2003 AAC/GAC 1585 529 Asn/Asp 2003 USA, Mexico, Central America, Southeast Asia, and Africa. Sequencing Whole gene H N/A E-Test 38/124 1/0 katG Trp397Tyr, no other mutations in the 19 genes sequenced. -
Cockerill FR JID 1995 GCC/GAC 1649 550 Ala/Asp 1995 USA Sequencing. Whole gene H 0.12->32ug/ml Proportion method - - "R strain also Ala424Val; S strain also Gln224Glu, Ala243Ser." -
Hai Hua Lin TubercRespirDis 2007 GCC/GGC 1652 551 Ala/Gly 2004 South Korea Sequencing Whole gene MDR N.S. N.S 29/29 1/0 None -
Secondary Publication: Hazbon MH AAC 2006 del C 1667 556 Frameshift - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TTC/TCC 1700 567 Phe/Ser - - - - - - - - - - -
Gagneux S PLOS Path 2006 GAT/AAT 1717 573 Asp/Asn - - - - - - - - - - -
Secondary Publication: Hazbon MH AAC 2006 GCG/GAG 1721 574 Ala/Glu - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GCG/GTG 1721 574 Ala/Val - - - - - - - - - - -
Secondary Publication: Hazbon MH AAC 2006 CTG/ATG 1759 587 Leu/Ile - - - - - - - - - - -
Heym B MolMicro 1995 CTG/ATG 1759 587 Leu/Met 1995 N.S. PCR-SSCP, Sequencing Whole gene H >5 ug/ml Proportion method 39/39 1/0 - -
Marttila HJ AAC 1996 CTG/CCG 1760 587 Leu/Pro 1989-1995 Finland Sequencing Whole gene H 0.4ug/ml disk elution method 54/56 1/0 - -
Cockerill FR JID 1995 CCC/ACC 1765 589 Pro/Thr 1995 USA PCR, RFLP, Sequencing. Whole gene H 32ug/ml Proportion method 40071 1/0 Arg429Leu, Ala264Thr in katG. -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GGC/GAC 1778 593 Gly/Asp - - - - - - - - - - -
Gagneux S PLOS Path 2006 GAG/AAG 1819 607 Glu/Lys - - - - - - - - - - -
Cockerill FR JID 1995 ATG/ATT, ATG/ATC or ATG/ATA 1827 609 Met/Ile 1995 USA PCR, RFLP, Sequencing. Whole gene H <0.12-32ug/ml Proportion method - - "The 2 R isolates also had Arg463Leu + one other mutation each; the S isolate had no other mutations." -
Marttila HJ AAC 1996 ins AC 1849 617 Frameshift 1989-1995 Finland Sequencing Whole gene H 1 ug/ml disk elution method 54/56 1/0 - -
Wei CJ AAC 2003 CTC/CCC 1856 619 Leu/Pro 2003 - - - - - - - - - -
Rouse DA AAC 1995 GGC/AGC 1888 629 Gly/Ser 1995 - PCR SSCP analysis Whole gene H 1ug/ml Absolute concentration method 26/26 1/0 - -
Wei CJ AAC 2003 CTC/TTC 1900 634 Leu/Phe 2003 - - - - - - - - - -
Gagneux S PLOS Path 2006 GCA/GAA 1907 636 Ala/Glu - - - - - - - - - - -
Gagneux S PLOS Path 2006 CTG/CCG 1958 653 Leu/Pro - - - - - - - - - - -
Zhang M J Clin Microb 2005 GGC/CGC 2053 685 Gly/Arg 2005 China Sequencing. Whole gene H 2ug/ml BACTEC MGIT 960 1/87 1/0 Ser315Thr in katG. -
Pretorius GS AAC 1995 GAC/GCC 2084 695 Asp/Ala 1995 South Africa PCR-SSCP, Sequencing - HRS 40 Agar dilution method 39/69 1/0 - -
Baker LV AAC 2005 GGG/GAG 2096 699 Gly/Gln 1998 United Kingdom Directed Oligonucleotide array, Sequencing Whole gene H,HS,HE,HSE,MDR ratio>=4 Resistance ratio method 202/378 1/0 - -
Marttila HJ AAC 1996 TCC/CCC 2098 700 Ser/Pro 1989-1995 Finland Sequencing Whole gene H 1 ug/ml disk elution method 54/56 1/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GTC/GCC 2129 710 Val/Ala - - - - - - - - - - -
Secondary Publication: Hazbon MH AAC 2006 GCC/CCC 2137 713 Ala/Pro - - - - - - - - - - -
Secondary Publication: Hazbon MH AAC 2006 CAG/CCG 2150 717 Gln/Pro - - - - - - - - - - -
Rouse DA AAC 1995 GCG/CCG 2146 716 Ala/Pro 1995 USA, South Korea PCR-SSCP Whole gene HRP 50ug/ml Absolute concentration method 26/26 1/0 - -
Ramaswamy SV J Med Micro 2004 GCC/GAC 2180 727 Ala/Asp 1996-1998 Mexico Directed Oligonucleotide array, Sequencing codon 228-357 HRS >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E Proportion method 37/50 1/0 Ser450Leu rpoB, nt491C/T rrs, Met306Ile embB -
Gagneux S PLOS Path 2006 TGG/TGT or TGG/TGC 2184 728 Trp/Cys - - - - - - - - - - -
Gagneux S PLOS Path 2006 del GAC 2203-2205 735 del Asp - - - - - - - - - - -
Gagneux S PLOS Path 2006 GAC/AAC 2203 735 Asp/Asn - - - - - - - - - - -
Wei CJ AAC 2003 GAC/GCC 2204 735 Asp/Ala 2003 - - - - - - - - - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator