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Rv1484 More about Rv1484 on TBDB.org More about Rv1484 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1484: all mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Hai Hua Lin TubercRespirDis 2007 | AAA/AAC | 24 | 8 | Lys/Asn | 2004 | South Korea | Sequencing | Whole gene | MDR | N.S. | N.S | 29/29 | 1/0 | inhA -15 (C/T) | - |
| Basso L JID 1998 | ATC/ACC | 47 | 16 | Ile/Thr | 1998 | USA | Sequencing | Whole gene | H | 1.0ug/ml | BACTEC | N.S. | 1/0 | none | - |
| Morlock GP AAC 2003 | ATC/GTC | 61 | 21 | Ile/Val | 2003 | USA | Sequencing | 284 bp inhA promoter and nt 13-379 of inhA | HEth | 8ug/mlI, >200ug/ml Eth | Proportion metho | 41/42 | 2/0 | C(-15)T inhA regulator | - |
| Morlock GP AAC 2003 | ATC/ACC | 62 | 21 | Ile/Thr | 2003 | USA | Sequencing | 284 bp inhA promoter and nt 13-379 of inhA | HEth | >32ug/ml, 8ug/ml I, >200 ug/ml or 100ug/ml Eth | Proportion method | 41/42 | 3/0 | C(-15)T, G(-17)T inhA regulator, | - |
| Basso L JID 1998 | ATT/ACT | 140 | 47 | Ile/Thr | 1998 | USA | Sequencing | Whole gene | H | 1.0 ug/ml | BACTEC | N.S. | 1/0 | none | - |
| Basso L JID 1998 | GTG/GCG | 233 | 78 | Val/Ala | 1998 | USA | Sequencing | Whole gene | H | 1.0 ug/ml | BACTEC | N.S. | 1/0 | none | - |
| Lee H Int J Tuberc Lung Dis 2000 | TCG/GCG | 280 | 94 | Ser/Ala | 2000 | South Korea | Sequencing | nt174-382 | HR | 0.2ug/ml I, 20ug/ml R | - | 24/24 | 1/0 | - | - |
| Vilcheze C Nat Med 2006 | TCG/TTG | 281 | 94 | Ser/Leu | - | - | - | - | - | - | - | - | - | - | - |
| Ristow M Lancet 1995 | ATT/CCT | 283-284 | 95 | Ile/Pro | 1995 | Germany, Nepal | Sequencing | inhA codon 94 | HEth | All 7 were resistant to I or Eth or both. | Proportion method | 38/47 | 7/0 | not mentioned | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | ATT/ACT | 284 | 95 | Ile/Thr | - | - | - | - | - | - | - | - | - | - | - |
| Leung ET AAC 2006 | ATC/ACC | 581 | 194 | Ile/Thr | 1999-2002 | Hong Kong, China | Sequencing | -38 to-13, 250-268,381-399,510-492,860-840, | H | >1ug/ml | Proportion method | 102/375 | 1/0 | not mentioned | - |
| Huang WL JCM 2009 | - | - | 202 | Arg/Gly | 2007-2008 | Taiwan | Sequencing | N.S. | 242MDR | N.S. | MGIT 960 | 242/272 | 1/0 | not mentiond | - |
| Huang WL JCM 2009 | - | - | 217 | Glu/Asp | 2007-2008 | Taiwan | Sequencing | N.S. | 242MDR | N.S. | MGIT 960 | 242/272 | 1/0 | not mentiond | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |