Rv0005: gyrBRv0006: gyrA

Rv0006

More about Rv0006 on    TBDB.org

More about Rv0006 on    TubercuList

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Display high confidence mutations only
Rv0006: high confidence mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Shi R JCM 2006 GCC/TCC 220 74 Ala/Ser 2002-2003 China Sequencing 227bp QRDR gyrA OFX OFL 2-32 Absolute concentration method 87/109 10/0 gyrA: Asp94Gly
Takiff HE AAC 1994 GCG/GTG 269 90 Ala/Val Published 1994 N.S. PCR-SSCP, Sequencing 320-bp QRDR of gyrA CIP CIP: 4-8 BACTEC 460 3/54 3/0 gyrA: Ser95Thr
Takiff HE AAC 1994 TCG/CCG 271 91 Ser/Pro Published 1994 N.S. PCR-SSCP, Sequencing 320-bp QRDR of gyrA CIP CIP: 4 BACTEC 460 1/54 1/0 gyrA: Ser95Thr
Takiff HE AAC 1994 GAC/AAC 280 94 Asp/Asn Published 1994 N.S. PCR-SSCP, Sequencing 320-bp QRDR of gyrA CIP CIP: 8 BACTEC 460 1/54 1/0 gyrA: Ser95Thr
Takiff HE AAC 1994 GAC/CAC 280 94 Asp/His Published 1994 N.S. PCR-SSCP, Sequencing 320-bp QRDR of gyrA CIP CIP: 4 BACTEC 460 1/54 1/0 gyrA: Ser95Thr
Takiff HE AAC 1994 GAC/TAC 280 94 Asp/Tyr Published 1994 N.S. PCR-SSCP, Sequencing 320-bp QRDR of gyrA CIP CIP: 8 BACTEC 460 2/54 2/0 gyrA: Ser95Thr
Takiff HE AAC 1994 GAC/GGC 281 94 Asp/Gly Published 1994 N.S. PCR-SSCP, Sequencing 320-bp QRDR of gyrA CIP CIP: 8 BACTEC 460 5/54 5/0 gyrA: Ser95Thr
Takiff HE AAC 1994 GAC/GCC 281 94 Asp/Ala Published 1994 N.S. PCR-SSCP, Sequencing 320-bp QRDR of gyrA CIP CIP: 4 BACTEC 460 1/54 1/0 gyrA: Ser95Thr
Kam KM Microb Drug Res 2006 CCC/CAC 305 102 Pro/His - - - - - - - - - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator