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Rv0005 More about Rv0005 on TBDB.org More about Rv0005 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail Display high confidence mutations only |
| Rv0005: high confidence mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Aubry A AAC 2006 | AAC/GAC | 1528 | 510 | Asn/Asp | Published 2006 | France | Sequencing | QRDRs on gyrA and gyrB | "GAT, MOX, LVX, and OFX; strongly resistant to ENX." | GAT: >1, MOX and LVX: 2, OFX: 4, and ENX: 64 | Proportion method | 14/15 | 1/0 | No other mutations in QRDR of gyrA or gyrB. |  |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |