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Rv0005 More about Rv0005 on TBDB.org More about Rv0005 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv0005: Codons 540 to 559: 1 mutation (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Mokrousov I AAC 2008 | CAA/CAT | 1647 | 549 | Gln/His | 2004 - 2005 | Taiwan | Sequencing | QRDRs on gyrA and gyrB | OFX, CIP, LVX, and MOX. Out of the 14 FQ-R isolates, 6 (42.9%) were resistant to at least one 1st-line drug, while 4 (28.6%) were multidrug-resistant. | OFX: 8, CIP: 5, LVX: 1, and MOX: 1 | Modified proportion method | 14/420 | 1/0 | No further mutations in gyrA or gyrB QRDRs found. | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |