Rv0005: gyrBRv0006: gyrA

Rv0005

More about Rv0005 on    TBDB.org

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Display high confidence mutations only
Rv0005: Codons 460 to 479: 5 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Duong DA AAC 2009 GAC/CAC 1414 472 Asp/His 2005-2007 Vietnam Sequencing QRDRs on gyrA and gyrB - - Proportion method 109/218 1/0 No other mutation in gyrA or gyrB -
Aubry A AAC 2006 GAC/CAC 1414 472 Asp/His Published 2006 France Sequencing QRDRs on gyrA and gyrB Strongly resistant to OFX OFX: 60ug/ml N.S. 14/15 1/0 "Ala90Val in gyrA; no other mutations in QRDR of gyrB." -
Pitaksajjakul P Southeast Asian J Trop Med Public Health 2005 GAC/AAC 1414 472 Asp/Asn Published 2005 Thailand PCR-SSCP, Sequencing "320-bp QRDR of gyrA; 429-bp QRDR of gyrB." INH+RIF+STR+EMB+OFX N.S. Absolute concentration method 35/35 1/0 No further mutations in gyrA or gyrB QRDRs found. -
Duong DA AAC 2009 GAC/AAC 1414 472 Asp/Asn 2005-2007 Vietnam Sequencing QRDRs on gyrA and gyrB - - Proportion method 109/218 1/0 gyrA D94A -
Duong DA AAC 2009 GAC/GCC 1415 472 Asp/Ala 2005-2007 Vietnam Sequencing QRDRs on gyrA and gyrB - - Proportion method 109/218 1/0 gyrA A90V -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator