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Rv0005 More about Rv0005 on TBDB.org More about Rv0005 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv0005: Codons 440 to 459: 2 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Feuerriegel S AAC 2009 | CGT/TGT | 1369 | 457 | Arg/Cys | 2003-2006 | Uzbekistan | Sequencing | QRDRs on gyrA and gyrB | OFX | N.S. | BACTEC 460 and MGIT 960 | 26/49 | 1/0 | - | - |
| Duong DA AAC 2009 | TCC/TTC | 1373 | 458 | Ser/Phe | 2005-2007 | Vietnam | Sequencing | QRDRs on gyrA and gyrB | - | - | Proportion method | 109/218 | 1/0 | No other mutation in gyrA or gyrB | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |