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Rv3854c More about Rv3854c on TBDB.org More about Rv3854c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3854c: Codons 50 to 59: 3 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| DeBarber AE PNAS 2000 | CCC/CTC | 152 | 51 | Pro/Leu | Published 2000 | South Africa | Sequencing | Whole gene | EthL | N.S. | Proportion method. | 40132 | 1/0 | None found in region analyzed. | - |
| Morlock GP AAC 2003 | GAC/GCC | 167 | 55 | Asp/Ala | Published 2003 | USA, Russia, Brazil | Sequencing | Whole gene | HEth | >200ug/ml | Microplate almar blue assay | 41/41 | 1/0 | katG Gly279Asp, mabA -15 C/T | - |
| DeBarber AE PNAS 2000 | GAC/GCC | 173 | 58 | Asp/Ala | Published 2000 | South Africa | Sequencing | Whole gene | Eth | N.S. | Proportion method. | 40132 | 1/0 | None found in region analyzed. | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |