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Rv3795 More about Rv3795 on TBDB.org More about Rv3795 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail Display high confidence mutations only |
| Rv3795: high confidence mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Sreevatsan S AAC 1997 | ATG/CTG | 916 | 306 | Met/Leu | Published 1997 | USA, Mexico, Europe, Yemen, the Philippines, Japan, India | PCR-SSCP, Sequencing | Whole gene | E | 40ug/ml | BACTEC 460, agar diffusion method | 69/99 | 1/0 | - |  |
| Sreevatsan S AAC 1997 | ATG/GTG | 916 | 306 | Met/Val | Published 1997 | USA, Mexico, Europe, Yemen, the Philippines, Japan, India | PCR-SSCP, Sequencing | Whole gene | E | 40ug/ml | BACTEC 460, agar diffusion method | 69/99 | 12/0 | - | |
| Sreevatsan S AAC 1997 | ATG/ATA | 918 | 306 | Met/Ile | Published 1997 | USA, Mexico, Europe, Yemen, the Philippines, Japan, India | PCR-SSCP, Sequencing | Whole gene | E | 20ug/ml | BACTEC 460, agar diffusion method | 69/99 | 11/0 | - | |
| Sreevatsan S AAC 1997 | ATG/ATT | 918 | 306 | Met/Ile | Published 1997 | USA, Mexico, Europe, Yemen, the Philippines, Japan, India | PCR-SSCP, Sequencing | Whole gene | E | 20ug/ml | BACTEC 460, agar diffusion method | 69/99 | 2/0 | - | |
| Sreevatsan S AAC 1997 | ATG/ATC | 918 | 306 | Met/Ile | Published 1997 | USA, Mexico, Europe, Yemen, the Philippines, Japan, India | PCR-SSCP, Sequencing | Whole gene | E | 20ug/ml | BACTEC 460, agar diffusion method | 69/99 | 3/0 | - | |
| Ramaswamy SV AAC 2000 | GGC/AGC | 1216 | 406 | Gly/Ser | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 30ug/ml | BACTEC 460, agar diffusion method | 75/108 | 1/0 | -43 CG deletion in embA. | |
| Ramaswamy SV AAC 2000 | GGC/GAC | 1217 | 406 | Gly/Asp | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 40ug/ml | BACTEC 460, agar diffusion method | 75/108 | 1/0 | Asp4Asn in embA | |
| Ramaswamy SV AAC 2000 | CAG/CGG | 1490 | 497 | Gln/Arg | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 30-50ug/ml | BACTEC 460, agar diffusion method | 75/108 | 3/0 | In one of the isolates: -12 C/T in embA, Ser501Trp in iniA. | |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |