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Rv3795 More about Rv3795 on TBDB.org More about Rv3795 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3795: Codons 450 to 474: 8 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Srivastava S JMM 2009 | GTG/CTG | 1354 | 452 | Val/Leu | Published 2009 | India | Sequencing | Whole gene | EHR | 256ug/ml | Proportion method, E-Test | 44/44 | 1/0 | embB L239P, Y315L, N318S, E378A, Y384N, N400K | - |
| Srivastava S JMM 2009 | GGC/GCG | 1376-1377 | 459 | Gly/Ala | Published 2009 | India | Sequencing | Whole gene | EHR | 32ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306V, N318K, N368A, S380R, P397Q, R460C; embR T32P, D53H" | - |
| Srivastava S JMM 2009 | CGT/TGC | 1378-1380 | 460 | Arg/Cys | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB E368A, S380R, P397Q; embC A244T, G288W, V303G embR L172R" | - |
| Srivastava S JMM 2009 | CGT/CTG | 1379-1380 | 460 | Arg/Leu | Published 2009 | India | Sequencing | Whole gene | EHR | 4ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB S347I, E368D; embC I297T; embR R230W, I396T" | - |
| Srivastava S JMM 2009 | CCG/AGC | 1381-1383 | 461 | Pro/Ser | Published 2009 | India | Sequencing | Whole gene | EHR | 128ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306V, V309G, A310R, D311R, V369A, P375A, F398Y; embC T270I; embR G240R" | - |
| Srivastava S CurrMicro 2006 | ATT/GAT | 1393-1394 | 465 | Ile/Asp | Published 2006 | India | Sequencing | ERDR | E, EHR, HR, EH | 2ug/ml | Proportion method, E-Test | 23/23 | 1/0 | "Asp299Glu, Glu378Ala, and Pro446His in embB; Thr270Ile and 254 Synonymous (GCC/GCG) in embC. R/T and R/S calculated from Table 1." | - |
| Srivastava S CurrMicro 2006 | CGT/CCG | 1406-1407 | 469 | Arg/Pro | Published 2006 | India | Sequencing | ERDR | E, EHR, HR, EH | 2ug/ml | Proportion method, E-Test | 23/23 | 1/0 | Asp299Glu, Glu378Ala, and Arg471Pro in embB. R/T and R/S calculated from Table 1. | - |
| Srivastava S CurrMicro 2006 | CGT/CCG | 1412-1413 | 471 | Arg/Pro | Published 2006 | India | Sequencing | ERDR | E, EHR, HR, EH | 2ug/ml | Proportion method, E-Test | 23/23 | 1/0 | Asp299Glu, Glu378Ala, and Arg469Pro in embB. R/T and R/S calculated from Table 1. | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |