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Rv3795 More about Rv3795 on TBDB.org More about Rv3795 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3795: Codons 425 to 449: 8 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Srivastava S JMM 2009 | CCG/CTG | 1289 | 430 | Pro/Leu | Published 2009 | India | Sequencing | Whole gene | EHR | 2ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB G406D, A431T; embC I297T" | - |
| Srivastava S JMM 2009 | GCG/ACC | 1291-1293 | 431 | Ala/Thr | Published 2009 | India | Sequencing | Whole gene | EHR | 2ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB G406D,P430L; embC I297T" | - |
| Srivastava S JMM 2009 | GCG/GGC | 1301-1302 | 434 | Arg/Gly | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306L, A356V, S366P, W395R, V435G, V436G, T437A; embC T270I" | - |
| Srivastava S JMM 2009 | GTG/GGC | 1304-1305 | 435 | Val/Gly | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306L, A356V, S366P, W395R, A434G, V436G, T437A; embC T270I" | - |
| Srivastava S JMM 2009 | GTG/GGC | 1307-1308 | 436 | Val/Gly | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306L, A356V, S366P, W395R, A434G, V435G, T437A; embC T270I" | - |
| Srivastava S JMM 2009 | ACC/GCG | 1309-1311 | 437 | Thr/Ala | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306L, A356V, S366P, W395R, A434G, V435G, V436G; embC T270I" | - |
| Srivastava S CurrMicro 2006 | CCG/CAT | 1337-1338 | 446 | Pro/His | Published 2006 | India | Sequencing | ERDR | E, EHR, HR, EH | 2ug/ml | Proportion method, E-Test | 23/23 | 1/0 | "Asp299Glu, Glu378Ala, and Ile465Asp in embB; Thr270Ile and 254 Synonymous (GCC/GCG) in embC. R/T and R/S calculated from Table 1." | - |
| Srivastava S JMM 2009 | GGC/GTG | 1343-1344 | 448 | Gly/Val | Published 2009 | India | Sequencing | Whole gene | EHR | 3ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB G358V, E368Q, S380D, P397T, G406D; embC I287L, W326R" | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |