Rv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1267c: embRRv3124Rv3125cRv3126Rv3264c: rmlA2Rv3266c: rmlDRv3793: embCRv3794: embARv3795: embB

Rv3795

More about Rv3795 on    TBDB.org

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Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only
Rv3795: Codons 400 to 424: 12 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Srivastava S JMM 2009 AAC/CCG 1198-1200 400 Asn/Pro Published 2009 India Sequencing Whole gene EH 4ug/ml Proportion method, E-Test 44/44 1/0 "embC G374V, W395C; embC G288W, V303G; embR A187V, R230W, I369T" -
Srivastava S JMM 2009 AAC/AAA 1200 400 Asn/Lys Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, N318S, E378A, Y384N, V452L -
Srivastava S JMM 2009 ACG/ACA 1203 401 Gly/Ser Published 2009 India Sequencing Whole gene ER 16ug/ml Proportion method, E-Test 44/44 1/0 "embB G331R, G374V, G374V; embC I297T; embR D223E" -
Srivastava S JMM 2009 GAA/CCG 1213-1214 405 Glu/Pro Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB L370R, V377M, E378A, F398H, N399H, G406A -
Srivastava S JMM 2009 GGC/CCG 1216 406 Gly/Pro Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, A379D, Y384N, A388G, N399D; embC A247P, T270I, I297T" -
Ramaswamy SV AAC 2000 GGC/AGC 1216 406 Gly/Ser Published 2000 USA, Russia Sequencing Whole gene E 30ug/ml BACTEC 460, agar diffusion method 75/108 1/0 -43 CG deletion in embA.
Ramaswamy SV AAC 2000 GGC/TGC 1216 406 Gly/Cys Published 2000 USA, Russia Sequencing Whole gene E 30-50ug/ml BACTEC 460, agar diffusion method 75/108 2/0 - -
Srivastava S JMM 2009 GGC/GAT 1217 406 Gly/Asp Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, S380D, P397T, G448V; embC I287L, W326R" -
Ramaswamy SV AAC 2000 GGC/GAC 1217 406 Gly/Asp Published 2000 USA, Russia Sequencing Whole gene E 40ug/ml BACTEC 460, agar diffusion method 75/108 1/0 Asp4Asn in embA
Ramaswamy SV AAC 2000 GGC/GCC 1217 406 Gly/Ala Published 2000 USA, Russia Sequencing Whole gene E 20ug/ml BACTEC 460, agar diffusion method 75/108 2/0 In one of the isolates, -11 C/A in embA and Met306Ile in embB. -
Srivastava S CurrMicro 2006 GGC/GCG 1190 406 Gly/Ala Published 2006 India Sequencing ERDR E, EHR, HR, EH 32ug/ml Proportion method 23/23 1/0 Met306Val, Glu368Ala, and Ser380Arg on embB. R/Tot and R/S calculated from Table 1. -
Lee AS AAC 2004 ATG/ATA 1269 423 Met/Ile Published 2004 Singapore Sequencing Whole gene EI N.S. BACTEC 460 25/45 1/0 None in region amplified (see Gene coverage). -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator