Rv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1267c: embRRv3124Rv3125cRv3126Rv3264c: rmlA2Rv3266c: rmlDRv3793: embCRv3794: embARv3795: embB

Rv3795

More about Rv3795 on    TBDB.org

More about Rv3795 on    TubercuList

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Display high confidence mutations only
Rv3795: Codons 375 to 399: 19 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Srivastava S JMM 2009 CCG/GCG 1123-1124 375 Pro/Ala Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A310R, D311R, V369A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 GTG/ATG 1129 377 Val/Met Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB L370R, E378A, F398H, N399H, E405P, G406A -
Srivastava S JMM 2009 GTG/GGC 1130-1131 377 Val/Gly Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, N318S, E378A, Y384N, N400K, V452L -
Srivastava S JMM 2009 GAA/AAA 1132 378 Glu/Lys Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, A356S, P371R; embR R230W, L292M, L303E" -
Srivastava S CurrMicro 2006 GAA/GCG 1103-1104 378 Glu/Ala Published 2006 India Sequencing ERDR E, EHR, HR, EH 2ug/ml Proportion method 23/23 2/0 Both of these isolates were mutated at embB Asp299Glu. One was also mutated at embB Pro446His and Ile465Asp, as well as embC Thr270Ile and 254 Synonymous (GCC/GCG). The other isolate was mutated at embBArg469Pro and Arg 471Pro. R/Tot and R/S calculated fr -
Srivastava S JMM 2009 GCG/ACC 1135-1137 379 Ala/Thr Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S; embC V287F, Y309N; embR L320V S326N, V350G, H351Q, R356G, I369T" -
Srivastava S JMM 2009 GCG/GAT 1136-1137 379 Ala/Asp Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, Y384N, A388G, N399D, G406P; embC A247P, T270I, I297T" -
Srivastava S CurrMicro 2006 AGC/CGT 1138-1140 380 Ser/Arg Published 2006 India Sequencing ERDR E, EHR, HR, EH 32ug/ml Proportion method 23/23 1/0 Met306Val, Glu368Ala, and Pro397Gln on embB. R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 AGC/AAC 1139 380 Ser/Asp Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, P397T, G406D, G448V; embC I287L, W326R" -
Srivastava S JMM 2009 TAT/AAC 1150-1152 384 Tyr/Asn Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, N318S, V377G, E378A, N400K, V452L -
Srivastava S JMM 2009 GCG/GGC 1163-1164 388 Ala/Gly Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, A379D, Y384N, N399D, G406P; embC A247P, T270I, I297T" -
Srivastava S JMM 2009 TGG/CGT 1183-1185 395 Trp/Arg Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, A356V, S366P, A434G, V435G, V436G, T437A; embC T270I" -
Srivastava S JMM 2009 TGG/TGC 1185 395 Trp/Cys Published 2009 India Sequencing Whole gene EH 4ug/ml Proportion method, E-Test 44/44 1/0 "embC G374V, N400P; embC G288W, V303G; embR A187V, R230W, I369T" -
Srivastava S JMM 2009 CCG/ACC 1189-1190 397 Pro/Thr Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, S380D, G406D, G448V; embC I287L, W326R" -
Srivastava S CurrMicro 2006 CCG/CAG 1190 397 Pro/Gln Published 2006 India Sequencing ERDR E, EHR, HR, EH 32ug/ml Proportion method 23/23 1/0 Met306Val, Glu368Ala, and Ser380Arg on embB. R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 TTT/CAT 1192-1193 398 Phe/His Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB L370R, V377M, E378A, N399H, E405P, G406A -
Srivastava S JMM 2009 TTT/TAT 1193 398 Phe/Tyr Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A310R, D311R, V369A, P375A, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 TTT/GAT 1195-1196 399 Asn/Asp Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, A379D, Y384N, A388G, G406P; embC A247P, T270I, I297T" -
Srivastava S JMM 2009 TTT/CAT 1195-1196 399 Asn/His Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB L370R, V377M, E378A, F398H, E405P, G406A -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator