|
|
           
|
|
|
|
|
|
|
|
 
|
|
Rv3795 More about Rv3795 on TBDB.org More about Rv3795 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3795: Codons 350 to 374: 18 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Srivastava S JMM 2009 | GCG/TTT | 1066-1068 | 356 | Ala/Phe | Published 2009 | India | Sequencing | Whole gene | EHR | 96ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB H312R, S317T, L359I, R367P; embC G288V, M310K, Y327N" | - |
| Srivastava S JMM 2009 | GCG/AGC | 1066-1068 | 356 | Ala/Ser | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB D299E, P371R, E378K; embR R230W, L292M, L303E" | - |
| Srivastava S JMM 2009 | GCG/GTG | 1067 | 356 | Ala/Val | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306L, S366P, W395R, A434G, V435G, V436G, T437A; embC T270I" | - |
| Srivastava S JMM 2009 | GCG/AGC | 1069-1071 | 357 | Ala/Ser | Published 2009 | India | Sequencing | Whole gene | EHR | 2ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB A379T; embC V287F, Y309N; embR L320V S326N, V350G, H351Q, R356G, I369T" | - |
| Srivastava S JMM 2009 | GCG/GTG | 1070 | 357 | Ala/Val | Published 2009 | India | Sequencing | Whole gene | EHR | 8ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB A356F, L359I, E378A, A379D, Y384N, A388G, N399D, G406P; embC A247P, T270I, I297T" | - |
| Srivastava S JMM 2009 | GGC/GTG | 1073-1074 | 358 | Gly/Val | Published 2009 | India | Sequencing | Whole gene | EHR | 3ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB E368Q, S380D, P397T, G406D, G448V; embC I287L, W326R" | - |
| Srivastava S JMM 2009 | CTG/ATT | 1075-1077 | 359 | Leu/Ile | Published 2009 | India | Sequencing | Whole gene | EHR | 96ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB H312R, S317T, A356F, R367P; embC G288V, M310K, Y327N" | - |
| Srivastava S JMM 2009 | GTG/ATG | 1078 | 360 | Val/Met | Published 2009 | India | Sequencing | Whole gene | ER | 16ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB G331R, G374V, G401S; embC I297T; embR D223E" | - |
| Srivastava S JMM 2009 | AGC/CCG | 1096 | 366 | Ser/Pro | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306L, A356V, W395R, A434G, V435G, V436G, T437A; embC T270I" | - |
| Srivastava S JMM 2009 | CGT/CCG | 1100-1101 | 367 | Arg/Pro | Published 2009 | India | Sequencing | Whole gene | EHR | 96ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB H312R, S317T, A356F, L359I; embC G288V, M310K, Y327N" | - |
| Srivastava S JMM 2009 | GAA/CAG | 1102-1104 | 368 | Glu/Gln | Published 2009 | India | Sequencing | Whole gene | EHR | 3ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB G358V, S380D, P397T, G406D, G448V; embC I287L, W326R" | - |
| Srivastava S JMM 2009 | GAA/GAT | 1104 | 368 | Glu/Asp | Published 2009 | India | Sequencing | Whole gene | EHR | 4ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB S347I, R460L; embC I297T; embR R230W, I396T" | - |
| Srivastava S CurrMicro 2006 | GAA/GCG | 1103-1104 | 368 | Glu/Ala | Published 2006 | India | Sequencing | ERDR | E, EHR, HR, EH | 32ug/ml | Proportion method | 23/23 | 1/0 | Met306Val, Ser380Arg, and Pro397Gln on embB. | - |
| Srivastava S JMM 2009 | GTG/CTG | 1105 | 369 | Val/Leu | Published 2009 | India | Sequencing | Whole gene | EHR | 12ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306I; embC L251R, A354G, T270I" | - |
| Srivastava S JMM 2009 | GTG/GCG | 1106 | 369 | Val/Ala | Published 2009 | India | Sequencing | Whole gene | EHR | 128ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306V, V309G, A310R, D311R, P375A, F398Y, P461S; embC T270I; embR G240R" | - |
| Srivastava S JMM 2009 | CTG/CGT | 1109-1110 | 370 | Leu/Arg | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | embB V377M, E378A, F398H, N399H, E405P, G406A | - |
| Srivastava S JMM 2009 | CCG/CGT | 1112-1113 | 371 | Pro/Arg | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB D299E, A356S, E378K; embR R230W, L292M, L303E" | - |
| Srivastava S JMM 2009 | GGC/GTG | 1121-1122 | 374 | Gly/Val | Published 2009 | India | Sequencing | Whole gene | EH | 4ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embC W395C, N400P; embC G288W, V303G; embR A187V, R230W, I369T" | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
|
© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |