Rv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1267c: embRRv3124Rv3125cRv3126Rv3264c: rmlA2Rv3266c: rmlDRv3793: embCRv3794: embARv3795: embB

Rv3795

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Display high confidence mutations only
Rv3795: Codons 300 to 324: 24 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Sreevatsan S AAC 1997 ATG/CTG 916 306 Met/Leu Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 40ug/ml BACTEC 460, agar diffusion method 69/99 1/0 -
Lee HY YonseiMedJ 2002 ATG/TTG 916 306 Met/Leu Published 2002 South Korea Sequencing Whole gene E, 2ug/ml Proportion method 21/26 1/0 None in region amplified (see Gene coverage). -
Sreevatsan S AAC 1997 ATG/GTG 916 306 Met/Val Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 40ug/ml BACTEC 460, agar diffusion method 69/99 12/0 -
Sreevatsan S AAC 1997 ATG/ATA 918 306 Met/Ile Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 20ug/ml BACTEC 460, agar diffusion method 69/99 11/0 -
Sreevatsan S AAC 1997 ATG/ATT 918 306 Met/Ile Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 20ug/ml BACTEC 460, agar diffusion method 69/99 2/0 -
Sreevatsan S AAC 1997 ATG/ATC 918 306 Met/Ile Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 20ug/ml BACTEC 460, agar diffusion method 69/99 3/0 -
Lee HY YonseiMedJ 2002 ATG/ACG 917-918 306 Met/Thr Published 2002 South Korea Sequencing ERDR E 2ug/ml Proportion method 21/26 1/0 None in region amplified (see Gene coverage). -
Srivastava S JMM 2009 GTG/GGC 926-927 309 Val/Gly Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, A310R, D311R, V369A, P375A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 GCG/CGT 928-930 310 Ala/Arg Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, D311R, V369A, P375A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 GAC/CGT 931-932 311 Asp/Arg Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A310R, V369A, P375A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S CurrMicro 2006 GAC/CAC 931 311 Asp/His Published 2006 India Sequencing ERDR E, EHR, HR, EH 12ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 CAT/CGT 935 312 His/Arg Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB S317T, A356F, L359I, R367P; embC G288V, M310K, Y327N" -
Lee HY YonseiMedJ 2002 GGC/GCG 941 314 Gly/Ala Published 2002 South Korea Sequencing ERDR E 4ug/ml Proportion method 21/26 1/0 Tyr322Cys on embB. -
Tracevska T ResMicro 2004 GGC/GAG 941-942 314 Gly/Glu "Published 2004; isolates collected in 2001-2002" Latvia Sequencing ERDR EHRS N.S. BACTEC radiorespiratory method (7.5ug/ml EMB), and absolute concentration method on L-J medium (cutoff 2.0ug/ml EMB) 33/66 1/0 None in region amplified (see Gene coverage). -
Srivastava S JMM 2009 TAT/CTG 943-945 315 Tyr/Leu Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, N318S, V377G, E378A, Y384N, N400K, V452L -
Srivastava S JMM 2009 AGC/ACC 950 317 Ser/Thr Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB H312R, A356F, L359I, R367P; embC G288V, M310K, Y327N" -
Srivastava S JMM 2009 AAC/CAT 352 318 Asn/His Published 2009 India Sequencing Whole gene EHR 16ug/ml Proportion method, E-Test 44/44 1/0 embC T270I -
Srivastava S JMM 2009 AAC/AGC 953 318 Asn/Ser Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, V377G, E378A, Y384N, N400K, V452L -
Srivastava S JMM 2009 AAC/AAA 954 318 Asn/Lys Published 2009 India Sequencing Whole gene EHR 32ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, N368A, S380R, P397Q, G459A, R460C; embR T32P, D53H" -
Sugawara I Jpn J Infect Dis 2005 TAT/GAT 955 319 Tyr/Cys - - - - - - - - - - -
Chan RCY JAC 2007 TAT/AAT 955 319 Tyr/Asn - - - - - - - - - - -
Sugawara I Jpn J Infect Dis 2005 TAT/TGT 956 319 Tyr/Cys - - - - - - - - - - -
Plinke C AAC 2006 TAT/TCT 956 319 Tyr/Ser 2001 Germany Sequencing ERDR EHR N.S. Proportion method, BACTEC 460 101/159 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Lee HY YonseiMedJ 2002 TAT/TGT 965 322 Tyr/Cys Published 2002 South Korea Sequencing ERDR E 4ug/ml Proportion method 21/26 1/0 Ala314Gly on embB. -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator