Rv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1267c: embRRv3124Rv3125cRv3126Rv3264c: rmlA2Rv3266c: rmlDRv3793: embCRv3794: embARv3795: embB

Rv3795

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Display high confidence mutations only
Rv3795: Codons 275 to 299: 13 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Jain A IndJMedRes 2008 GCG/CCG 841 281 Ala/Pro 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 TTT/CTG 841-843 281 Phe/Leu 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 GTG/GGG 845 282 Val/Gly Published 2009 India Sequencing Whole gene EHR 12ug/ml Proportion method, E-Test 44/44 1/0 None in region embB, embC or embR' -
Jain A IndJMedRes 2008 GTG/CTG 844 282 Val/Leu 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Sreevatsan S AAC 1997 TTC/TTA 855 285 Phe/Leu Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E N.S. BACTEC 460, agar diffusion method 69/99 1/0 - -
Jain A IndJMedRes 2008 TTT/TGC 860-861 287 Phe/Cys 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 TTT/GTG 859-861 287 Phe/Val 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 ATT/AAC 878-879 293 Ile/Asn 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 GGC/AGC 880 294 Gly/Ser 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 AAT/AAA 888 296 Asn/Lys Published 2009 India Sequencing Whole gene EHR 16ug/ml Proportion method, E-Test 44/44 1/0 "embB E368D, G406S; embC I297T" -
Ramaswamy SV AAC 2000 TCG/GCG 889 297 Ser/Ala Published 2000 USA, Russia Sequencing Whole gene E 10-50ug/ml BACTEC 460, agar diffusion method 75/108 1/0 - -
Plinke C AAC 2006 TCG/TTG 890 297 Ser/Leu 2001 Germany Sequencing ERDR E + INH + RIF N.S. Proportion method, BACTEC 460 101/159 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S CurrMicro 2006 GAC/GAA 897 299 Asp/Glu Published 2006 India Sequencing ERDR E, EHR, HR, EH 2-6ug/ml Proportion method, E-Test 23/23 4/0 "Out of 4 isolates, 2 were WT in all other loci analyzed except for a synonymous mutation (GCA/GCC) at embB259. These isolates had MIC=4-6ug/ml. Both other isolates contained the embB mutation Glu378Ala (GAA/GCG); one of them was also mutated at embB Pro44" -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator