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Rv3795 More about Rv3795 on TBDB.org More about Rv3795 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3795: Codons 250 to 274: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Srivastava S JMM 2009 | CGT/TGG | 769-771 | 257 | Arg/Trp | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embC V287F, Y309N; embR A176V, R230W, I369T" | - |
| Jain A IndJMedRes 2008 | GCG/GTG | 812 | 271 | Ala/Val | 2002-2004 | India | Sequencing | ERDR | EHRS | >20ug/ml | Proportion method, E-Test | 23/23 | 1/0 | None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. | - |
| Jain A IndJMedRes 2008 | AGC/TGC | 814 | 272 | Ser/Cys | 2002-2004 | India | Sequencing | ERDR | EHRS | >20ug/ml | Proportion method, E-Test | 23/23 | 1/0 | None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. | - |
| Jain A IndJMedRes 2008 | AGC/ATT | 815-816 | 272 | Ser/Ile | 2002-2004 | India | Sequencing | ERDR | EHRS | >20ug/ml | Proportion method, E-Test | 23/23 | 1/0 | None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. | - |
| Wu X Chinese J of Antibiotics 2002 | CGC/CCC | 821 | 274 | Arg/Pro | - | - | - | - | - | - | - | - | - | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |