Rv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1267c: embRRv3124Rv3125cRv3126Rv3264c: rmlA2Rv3266c: rmlDRv3793: embCRv3794: embARv3795: embB

Rv3795

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Display high confidence mutations only
Rv3795: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Srivastava S CurrMicro 2006 GTC/GGG 383 128 Val/Gly Published 2006 India Sequencing ERDR E, EHR, HR, EH 5ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 GCG/GGC 662-663 221 Ala/Gly 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 GCG/AGC 673-674 225 Ala/Ser 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 GTG/GGC 680-681 227 Val/Gly 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S CurrMicro 2006 CTC/CCC 716 239 Leu/Pro Published 2006 India Sequencing ERDR E, EHR, HR, EH 256ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S CurrMicro 2006 GAC/CAC 718 240 Asp/His Published 2006 India Sequencing ERDR E, EHR, HR, EH 4ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 CGT/TGG 769-771 257 Arg/Trp Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embC V287F, Y309N; embR A176V, R230W, I369T" -
Jain A IndJMedRes 2008 GCG/GTG 812 271 Ala/Val 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 AGC/TGC 814 272 Ser/Cys 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 AGC/ATT 815-816 272 Ser/Ile 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Wu X Chinese J of Antibiotics 2002 CGC/CCC 821 274 Arg/Pro - - - - - - - - - - -
Jain A IndJMedRes 2008 GCG/CCG 841 281 Ala/Pro 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 TTT/CTG 841-843 281 Phe/Leu 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 GTG/GGG 845 282 Val/Gly Published 2009 India Sequencing Whole gene EHR 12ug/ml Proportion method, E-Test 44/44 1/0 None in region embB, embC or embR' -
Jain A IndJMedRes 2008 GTG/CTG 844 282 Val/Leu 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Sreevatsan S AAC 1997 TTC/TTA 855 285 Phe/Leu Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E N.S. BACTEC 460, agar diffusion method 69/99 1/0 - -
Jain A IndJMedRes 2008 TTT/TGC 860-861 287 Phe/Cys 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 TTT/GTG 859-861 287 Phe/Val 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 ATT/AAC 878-879 293 Ile/Asn 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Jain A IndJMedRes 2008 GGC/AGC 880 294 Gly/Ser 2002-2004 India Sequencing ERDR EHRS >20ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 AAT/AAA 888 296 Asn/Lys Published 2009 India Sequencing Whole gene EHR 16ug/ml Proportion method, E-Test 44/44 1/0 "embB E368D, G406S; embC I297T" -
Ramaswamy SV AAC 2000 TCG/GCG 889 297 Ser/Ala Published 2000 USA, Russia Sequencing Whole gene E 10-50ug/ml BACTEC 460, agar diffusion method 75/108 1/0 - -
Plinke C AAC 2006 TCG/TTG 890 297 Ser/Leu 2001 Germany Sequencing ERDR E + INH + RIF N.S. Proportion method, BACTEC 460 101/159 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S CurrMicro 2006 GAC/GAA 897 299 Asp/Glu Published 2006 India Sequencing ERDR E, EHR, HR, EH 2-6ug/ml Proportion method, E-Test 23/23 4/0 "Out of 4 isolates, 2 were WT in all other loci analyzed except for a synonymous mutation (GCA/GCC) at embB259. These isolates had MIC=4-6ug/ml. Both other isolates contained the embB mutation Glu378Ala (GAA/GCG); one of them was also mutated at embB Pro44" -
Sreevatsan S AAC 1997 ATG/CTG 916 306 Met/Leu Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 40ug/ml BACTEC 460, agar diffusion method 69/99 1/0 -
Lee HY YonseiMedJ 2002 ATG/TTG 916 306 Met/Leu Published 2002 South Korea Sequencing Whole gene E, 2ug/ml Proportion method 21/26 1/0 None in region amplified (see Gene coverage). -
Sreevatsan S AAC 1997 ATG/GTG 916 306 Met/Val Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 40ug/ml BACTEC 460, agar diffusion method 69/99 12/0 -
Sreevatsan S AAC 1997 ATG/ATA 918 306 Met/Ile Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 20ug/ml BACTEC 460, agar diffusion method 69/99 11/0 -
Sreevatsan S AAC 1997 ATG/ATT 918 306 Met/Ile Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 20ug/ml BACTEC 460, agar diffusion method 69/99 2/0 -
Sreevatsan S AAC 1997 ATG/ATC 918 306 Met/Ile Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 20ug/ml BACTEC 460, agar diffusion method 69/99 3/0 -
Lee HY YonseiMedJ 2002 ATG/ACG 917-918 306 Met/Thr Published 2002 South Korea Sequencing ERDR E 2ug/ml Proportion method 21/26 1/0 None in region amplified (see Gene coverage). -
Srivastava S JMM 2009 GTG/GGC 926-927 309 Val/Gly Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, A310R, D311R, V369A, P375A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 GCG/CGT 928-930 310 Ala/Arg Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, D311R, V369A, P375A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 GAC/CGT 931-932 311 Asp/Arg Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A310R, V369A, P375A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S CurrMicro 2006 GAC/CAC 931 311 Asp/His Published 2006 India Sequencing ERDR E, EHR, HR, EH 12ug/ml Proportion method, E-Test 23/23 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 CAT/CGT 935 312 His/Arg Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB S317T, A356F, L359I, R367P; embC G288V, M310K, Y327N" -
Lee HY YonseiMedJ 2002 GGC/GCG 941 314 Gly/Ala Published 2002 South Korea Sequencing ERDR E 4ug/ml Proportion method 21/26 1/0 Tyr322Cys on embB. -
Tracevska T ResMicro 2004 GGC/GAG 941-942 314 Gly/Glu "Published 2004; isolates collected in 2001-2002" Latvia Sequencing ERDR EHRS N.S. BACTEC radiorespiratory method (7.5ug/ml EMB), and absolute concentration method on L-J medium (cutoff 2.0ug/ml EMB) 33/66 1/0 None in region amplified (see Gene coverage). -
Srivastava S JMM 2009 TAT/CTG 943-945 315 Tyr/Leu Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, N318S, V377G, E378A, Y384N, N400K, V452L -
Srivastava S JMM 2009 AGC/ACC 950 317 Ser/Thr Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB H312R, A356F, L359I, R367P; embC G288V, M310K, Y327N" -
Srivastava S JMM 2009 AAC/CAT 352 318 Asn/His Published 2009 India Sequencing Whole gene EHR 16ug/ml Proportion method, E-Test 44/44 1/0 embC T270I -
Srivastava S JMM 2009 AAC/AGC 953 318 Asn/Ser Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, V377G, E378A, Y384N, N400K, V452L -
Srivastava S JMM 2009 AAC/AAA 954 318 Asn/Lys Published 2009 India Sequencing Whole gene EHR 32ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, N368A, S380R, P397Q, G459A, R460C; embR T32P, D53H" -
Sugawara I Jpn J Infect Dis 2005 TAT/GAT 955 319 Tyr/Cys - - - - - - - - - - -
Chan RCY JAC 2007 TAT/AAT 955 319 Tyr/Asn - - - - - - - - - - -
Sugawara I Jpn J Infect Dis 2005 TAT/TGT 956 319 Tyr/Cys - - - - - - - - - - -
Plinke C AAC 2006 TAT/TCT 956 319 Tyr/Ser 2001 Germany Sequencing ERDR EHR N.S. Proportion method, BACTEC 460 101/159 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Lee HY YonseiMedJ 2002 TAT/TGT 965 322 Tyr/Cys Published 2002 South Korea Sequencing ERDR E 4ug/ml Proportion method 21/26 1/0 Ala314Gly on embB. -
Ramaswamy SV AAC 2000 GAT/TAT 982 328 Asp/Tyr Published 2000 USA, Russia Sequencing Whole gene E 30ug/ml BACTEC 460, agar diffusion method 75/108 1/0 Ala201Thr in embA, Tyr334His in embB. -
Ramaswamy SV AAC 2000 GAT/GGT 983 328 Asp/Gly Published 2000 USA, Russia Sequencing Whole gene E 10-50ug/ml BACTEC 460, agar diffusion method 75/108 1/0 - -
Plinke C AAC 2006 GAT/GTG 983-984 328 Asp/Val 2001 Germany Sequencing ERDR EHR N.S. Proportion method, BACTEC 460 101/159 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Escalante P TuberLung Dis 1998 del A 983 - Frameshift "Published 1998; isolates collected 1995-1996" Peru Sequencing ERDR E N.S. Proportion method 40146 1/0 None in region amplified (see Gene coverage). -
Sreevatsan S AAC 1997 TTC/GTC 988 330 Phe/Val Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 40ug/ml BACTEC 460, agar diffusion method 69/99 1/0 - -
Srivastava S JMM 2009 GGC/CGT 991-993 331 Gly/Arg Published 2009 India Sequencing Whole gene ER 16ug/ml Proportion method, E-Test 44/44 1/0 "embB V360M, G374V, G401S; embC I297T; embR D223E" -
Lee HY YonseiMedJ 2002 GAT/TAT 991 331 Asp/Tyr Published 2002 Korea Sequencing ERDR E 4ug/ml Proportion method 21/26 1/0 None in region amplified (see Gene coverage). -
Plinke C AAC 2006 TGG/CTG 994-995 332 Trp/Leu 2001 Germany Sequencing ERDR EHR N.S. Proportion method, BACTEC 460 101/159 1/0 None in region amplified (see Gene coverage). R/Tot and R/S calculated from Table 1. -
Sugawara I Jpn J Infect Dis 2005 TAT/CAT 997 333 Tyr/His - - - - - - - - - - -
Ramaswamy SV AAC 2000 TAC/CAC 1000 334 Tyr/His Published 2000 USA, Russia Sequencing Whole gene E 30ug/ml BACTEC 460, agar diffusion method 75/108 1/0 Ala201Thr in embA, Asp328Tyr in embB. -
Escalante P TuberLung Dis 1998 AGT/ACT 1040 347 Ser/Thr "Published 1998; isolates collected 1995-1996" Peru Sequencing ERDR E N.S. Proportion method 40146 1/0 None in region amplified (see Gene coverage). -
Srivastava S JMM 2009 AGT/ATT 1040 347 Ser/Ile Published 2009 India Sequencing Whole gene EHR 4ug/ml Proportion method, E-Test 44/44 1/0 "embB E368D, R460L; embC I297T; embR R230W, I396T" -
Srivastava S JMM 2009 GCG/TTT 1066-1068 356 Ala/Phe Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB H312R, S317T, L359I, R367P; embC G288V, M310K, Y327N" -
Srivastava S JMM 2009 GCG/AGC 1066-1068 356 Ala/Ser Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, P371R, E378K; embR R230W, L292M, L303E" -
Srivastava S JMM 2009 GCG/GTG 1067 356 Ala/Val Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, S366P, W395R, A434G, V435G, V436G, T437A; embC T270I" -
Srivastava S JMM 2009 GCG/AGC 1069-1071 357 Ala/Ser Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A379T; embC V287F, Y309N; embR L320V S326N, V350G, H351Q, R356G, I369T" -
Srivastava S JMM 2009 GCG/GTG 1070 357 Ala/Val Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, L359I, E378A, A379D, Y384N, A388G, N399D, G406P; embC A247P, T270I, I297T" -
Srivastava S JMM 2009 GGC/GTG 1073-1074 358 Gly/Val Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB E368Q, S380D, P397T, G406D, G448V; embC I287L, W326R" -
Srivastava S JMM 2009 CTG/ATT 1075-1077 359 Leu/Ile Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB H312R, S317T, A356F, R367P; embC G288V, M310K, Y327N" -
Srivastava S JMM 2009 GTG/ATG 1078 360 Val/Met Published 2009 India Sequencing Whole gene ER 16ug/ml Proportion method, E-Test 44/44 1/0 "embB G331R, G374V, G401S; embC I297T; embR D223E" -
Srivastava S JMM 2009 AGC/CCG 1096 366 Ser/Pro Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, A356V, W395R, A434G, V435G, V436G, T437A; embC T270I" -
Srivastava S JMM 2009 CGT/CCG 1100-1101 367 Arg/Pro Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB H312R, S317T, A356F, L359I; embC G288V, M310K, Y327N" -
Srivastava S JMM 2009 GAA/CAG 1102-1104 368 Glu/Gln Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, S380D, P397T, G406D, G448V; embC I287L, W326R" -
Srivastava S JMM 2009 GAA/GAT 1104 368 Glu/Asp Published 2009 India Sequencing Whole gene EHR 4ug/ml Proportion method, E-Test 44/44 1/0 "embB S347I, R460L; embC I297T; embR R230W, I396T" -
Srivastava S CurrMicro 2006 GAA/GCG 1103-1104 368 Glu/Ala Published 2006 India Sequencing ERDR E, EHR, HR, EH 32ug/ml Proportion method 23/23 1/0 Met306Val, Ser380Arg, and Pro397Gln on embB. -
Srivastava S JMM 2009 GTG/CTG 1105 369 Val/Leu Published 2009 India Sequencing Whole gene EHR 12ug/ml Proportion method, E-Test 44/44 1/0 "embB M306I; embC L251R, A354G, T270I" -
Srivastava S JMM 2009 GTG/GCG 1106 369 Val/Ala Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A310R, D311R, P375A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 CTG/CGT 1109-1110 370 Leu/Arg Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB V377M, E378A, F398H, N399H, E405P, G406A -
Srivastava S JMM 2009 CCG/CGT 1112-1113 371 Pro/Arg Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, A356S, E378K; embR R230W, L292M, L303E" -
Srivastava S JMM 2009 GGC/GTG 1121-1122 374 Gly/Val Published 2009 India Sequencing Whole gene EH 4ug/ml Proportion method, E-Test 44/44 1/0 "embC W395C, N400P; embC G288W, V303G; embR A187V, R230W, I369T" -
Srivastava S JMM 2009 CCG/GCG 1123-1124 375 Pro/Ala Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A310R, D311R, V369A, F398Y, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 GTG/ATG 1129 377 Val/Met Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB L370R, E378A, F398H, N399H, E405P, G406A -
Srivastava S JMM 2009 GTG/GGC 1130-1131 377 Val/Gly Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, N318S, E378A, Y384N, N400K, V452L -
Srivastava S JMM 2009 GAA/AAA 1132 378 Glu/Lys Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, A356S, P371R; embR R230W, L292M, L303E" -
Srivastava S CurrMicro 2006 GAA/GCG 1103-1104 378 Glu/Ala Published 2006 India Sequencing ERDR E, EHR, HR, EH 2ug/ml Proportion method 23/23 2/0 Both of these isolates were mutated at embB Asp299Glu. One was also mutated at embB Pro446His and Ile465Asp, as well as embC Thr270Ile and 254 Synonymous (GCC/GCG). The other isolate was mutated at embBArg469Pro and Arg 471Pro. R/Tot and R/S calculated fr -
Srivastava S JMM 2009 GCG/ACC 1135-1137 379 Ala/Thr Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S; embC V287F, Y309N; embR L320V S326N, V350G, H351Q, R356G, I369T" -
Srivastava S JMM 2009 GCG/GAT 1136-1137 379 Ala/Asp Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, Y384N, A388G, N399D, G406P; embC A247P, T270I, I297T" -
Srivastava S CurrMicro 2006 AGC/CGT 1138-1140 380 Ser/Arg Published 2006 India Sequencing ERDR E, EHR, HR, EH 32ug/ml Proportion method 23/23 1/0 Met306Val, Glu368Ala, and Pro397Gln on embB. R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 AGC/AAC 1139 380 Ser/Asp Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, P397T, G406D, G448V; embC I287L, W326R" -
Srivastava S JMM 2009 TAT/AAC 1150-1152 384 Tyr/Asn Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, N318S, V377G, E378A, N400K, V452L -
Srivastava S JMM 2009 GCG/GGC 1163-1164 388 Ala/Gly Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, A379D, Y384N, N399D, G406P; embC A247P, T270I, I297T" -
Srivastava S JMM 2009 TGG/CGT 1183-1185 395 Trp/Arg Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, A356V, S366P, A434G, V435G, V436G, T437A; embC T270I" -
Srivastava S JMM 2009 TGG/TGC 1185 395 Trp/Cys Published 2009 India Sequencing Whole gene EH 4ug/ml Proportion method, E-Test 44/44 1/0 "embC G374V, N400P; embC G288W, V303G; embR A187V, R230W, I369T" -
Srivastava S JMM 2009 CCG/ACC 1189-1190 397 Pro/Thr Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, S380D, G406D, G448V; embC I287L, W326R" -
Srivastava S CurrMicro 2006 CCG/CAG 1190 397 Pro/Gln Published 2006 India Sequencing ERDR E, EHR, HR, EH 32ug/ml Proportion method 23/23 1/0 Met306Val, Glu368Ala, and Ser380Arg on embB. R/Tot and R/S calculated from Table 1. -
Srivastava S JMM 2009 TTT/CAT 1192-1193 398 Phe/His Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB L370R, V377M, E378A, N399H, E405P, G406A -
Srivastava S JMM 2009 TTT/TAT 1193 398 Phe/Tyr Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A310R, D311R, V369A, P375A, P461S; embC T270I; embR G240R" -
Srivastava S JMM 2009 TTT/GAT 1195-1196 399 Asn/Asp Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, A379D, Y384N, A388G, G406P; embC A247P, T270I, I297T" -
Srivastava S JMM 2009 TTT/CAT 1195-1196 399 Asn/His Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB L370R, V377M, E378A, F398H, E405P, G406A -
Srivastava S JMM 2009 AAC/CCG 1198-1200 400 Asn/Pro Published 2009 India Sequencing Whole gene EH 4ug/ml Proportion method, E-Test 44/44 1/0 "embC G374V, W395C; embC G288W, V303G; embR A187V, R230W, I369T" -
Srivastava S JMM 2009 AAC/AAA 1200 400 Asn/Lys Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, N318S, E378A, Y384N, V452L -
Srivastava S JMM 2009 ACG/ACA 1203 401 Gly/Ser Published 2009 India Sequencing Whole gene ER 16ug/ml Proportion method, E-Test 44/44 1/0 "embB G331R, G374V, G374V; embC I297T; embR D223E" -
Srivastava S JMM 2009 GAA/CCG 1213-1214 405 Glu/Pro Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embB L370R, V377M, E378A, F398H, N399H, G406A -
Srivastava S JMM 2009 GGC/CCG 1216 406 Gly/Pro Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, A379D, Y384N, A388G, N399D; embC A247P, T270I, I297T" -
Ramaswamy SV AAC 2000 GGC/AGC 1216 406 Gly/Ser Published 2000 USA, Russia Sequencing Whole gene E 30ug/ml BACTEC 460, agar diffusion method 75/108 1/0 -43 CG deletion in embA.
Ramaswamy SV AAC 2000 GGC/TGC 1216 406 Gly/Cys Published 2000 USA, Russia Sequencing Whole gene E 30-50ug/ml BACTEC 460, agar diffusion method 75/108 2/0 - -
Srivastava S JMM 2009 GGC/GAT 1217 406 Gly/Asp Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, S380D, P397T, G448V; embC I287L, W326R" -
Ramaswamy SV AAC 2000 GGC/GAC 1217 406 Gly/Asp Published 2000 USA, Russia Sequencing Whole gene E 40ug/ml BACTEC 460, agar diffusion method 75/108 1/0 Asp4Asn in embA
Ramaswamy SV AAC 2000 GGC/GCC 1217 406 Gly/Ala Published 2000 USA, Russia Sequencing Whole gene E 20ug/ml BACTEC 460, agar diffusion method 75/108 2/0 In one of the isolates, -11 C/A in embA and Met306Ile in embB. -
Srivastava S CurrMicro 2006 GGC/GCG 1190 406 Gly/Ala Published 2006 India Sequencing ERDR E, EHR, HR, EH 32ug/ml Proportion method 23/23 1/0 Met306Val, Glu368Ala, and Ser380Arg on embB. R/Tot and R/S calculated from Table 1. -
Lee AS AAC 2004 ATG/ATA 1269 423 Met/Ile Published 2004 Singapore Sequencing Whole gene EI N.S. BACTEC 460 25/45 1/0 None in region amplified (see Gene coverage). -
Srivastava S JMM 2009 CCG/CTG 1289 430 Pro/Leu Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB G406D, A431T; embC I297T" -
Srivastava S JMM 2009 GCG/ACC 1291-1293 431 Ala/Thr Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB G406D,P430L; embC I297T" -
Srivastava S JMM 2009 GCG/GGC 1301-1302 434 Arg/Gly Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, A356V, S366P, W395R, V435G, V436G, T437A; embC T270I" -
Srivastava S JMM 2009 GTG/GGC 1304-1305 435 Val/Gly Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, A356V, S366P, W395R, A434G, V436G, T437A; embC T270I" -
Srivastava S JMM 2009 GTG/GGC 1307-1308 436 Val/Gly Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, A356V, S366P, W395R, A434G, V435G, T437A; embC T270I" -
Srivastava S JMM 2009 ACC/GCG 1309-1311 437 Thr/Ala Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, A356V, S366P, W395R, A434G, V435G, V436G; embC T270I" -
Srivastava S CurrMicro 2006 CCG/CAT 1337-1338 446 Pro/His Published 2006 India Sequencing ERDR E, EHR, HR, EH 2ug/ml Proportion method, E-Test 23/23 1/0 "Asp299Glu, Glu378Ala, and Ile465Asp in embB; Thr270Ile and 254 Synonymous (GCC/GCG) in embC. R/T and R/S calculated from Table 1." -
Srivastava S JMM 2009 GGC/GTG 1343-1344 448 Gly/Val Published 2009 India Sequencing Whole gene EHR 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, S380D, P397T, G406D; embC I287L, W326R" -
Srivastava S JMM 2009 GTG/CTG 1354 452 Val/Leu Published 2009 India Sequencing Whole gene EHR 256ug/ml Proportion method, E-Test 44/44 1/0 embB L239P, Y315L, N318S, E378A, Y384N, N400K -
Srivastava S JMM 2009 GGC/GCG 1376-1377 459 Gly/Ala Published 2009 India Sequencing Whole gene EHR 32ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, N318K, N368A, S380R, P397Q, R460C; embR T32P, D53H" -
Srivastava S JMM 2009 CGT/TGC 1378-1380 460 Arg/Cys Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB E368A, S380R, P397Q; embC A244T, G288W, V303G embR L172R" -
Srivastava S JMM 2009 CGT/CTG 1379-1380 460 Arg/Leu Published 2009 India Sequencing Whole gene EHR 4ug/ml Proportion method, E-Test 44/44 1/0 "embB S347I, E368D; embC I297T; embR R230W, I396T" -
Srivastava S JMM 2009 CCG/AGC 1381-1383 461 Pro/Ser Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A310R, D311R, V369A, P375A, F398Y; embC T270I; embR G240R" -
Srivastava S CurrMicro 2006 ATT/GAT 1393-1394 465 Ile/Asp Published 2006 India Sequencing ERDR E, EHR, HR, EH 2ug/ml Proportion method, E-Test 23/23 1/0 "Asp299Glu, Glu378Ala, and Pro446His in embB; Thr270Ile and 254 Synonymous (GCC/GCG) in embC. R/T and R/S calculated from Table 1." -
Srivastava S CurrMicro 2006 CGT/CCG 1406-1407 469 Arg/Pro Published 2006 India Sequencing ERDR E, EHR, HR, EH 2ug/ml Proportion method, E-Test 23/23 1/0 Asp299Glu, Glu378Ala, and Arg471Pro in embB. R/T and R/S calculated from Table 1. -
Srivastava S CurrMicro 2006 CGT/CCG 1412-1413 471 Arg/Pro Published 2006 India Sequencing ERDR E, EHR, HR, EH 2ug/ml Proportion method, E-Test 23/23 1/0 Asp299Glu, Glu378Ala, and Arg469Pro in embB. R/T and R/S calculated from Table 1. -
Ramaswamy SV AAC 2000 CAG/CGG 1490 497 Gln/Arg Published 2000 USA, Russia Sequencing Whole gene E 30-50ug/ml BACTEC 460, agar diffusion method 75/108 3/0 In one of the isolates: -12 C/T in embA, Ser501Trp in iniA.
Ramaswamy SV AAC 2000 CAG/AAG 1490 497 Gln/Lys Published 2000 USA, Russia Sequencing Whole gene E 30-50ug/ml BACTEC 460, agar diffusion method 75/108 2/0 "-12 C/T in embA at MIC=30ug/ml; -89 C/T in iniB at MIC>50ug/ml." -
Sreevatsan S AAC 1997 ACC/ATC 1889 630 Thr/Ile Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E >40ug/ml BACTEC 460, agar diffusion method 69/99 2/0 - -
Lee AS AAC 2004 GCG/ACG 1975 659 Ala/Thr Published 2004 Singapore Sequencing Whole gene ES N.S. BACTEC 460 25/45 0/1 None in region amplified (see Gene coverage). -
Ramaswamy SV AAC 2000 GGC/GAC 2234 745 Gly/Asp Published 2000 USA, Russia Sequencing Whole gene E 40ug/ml BACTEC 460, agar diffusion method 75/108 1/0 Gly308Arg in iniA -
Ramaswamy SV AAC 2000 GAC/GCC 2876 959 Asp/Ala Published 2000 USA, Russia Sequencing Whole gene E 10-50ug/ml BACTEC 460, agar diffusion method 75/108 1/0 - -
Ramaswamy SV AAC 2000 ATG/AGG 2999 1000 Met/Arg Published 2000 USA, Russia Sequencing Whole gene E 10-50ug/ml BACTEC 460, agar diffusion method 75/108 1/0 - -
Ramaswamy SV AAC 2000 GAC/AAC 3070 1024 Asp/Asn Published 2000 USA, Russia Sequencing Whole gene E 10-50ug/ml BACTEC 460, agar diffusion method 75/108 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator