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Rv3794 More about Rv3794 on TBDB.org More about Rv3794 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3794: all mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Ramaswamy SV AAC 2000 | del CG | -43 | -43 | Frameshift | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 20-30ug/ml | BACTEC 460 | 75/108 | 2/0 | "Met306Ile in embB at MIC=20ug/ml; Gly406Ser in embB at MIC=30ug/ml." | - |
| Ramaswamy SV AAC 2000 | C/T | -16 | -16 | - | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 10-40ug/ml | BACTEC 460 | 75/108 | 2/0 | "Arg738Gln in embC, Met306Ile in embB, and Pro54Ser in Rv3124 at MIC=40ug/ml; Ser501Trp at MIC>10ug/mL." | - |
| Ramaswamy SV AAC 2000 | C/T | -12 | -12 | - | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 30ug/ml | BACTEC 460 | 75/108 | 2/0 | "Gln497Lys in embB in one isolate; Gln497Lys in embB and Ser501Trp in iniA in another isolate." | - |
| Ramaswamy SV AAC 2000 | C/A | -11 | -11 | - | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 20ug/ml | BACTEC 460 | 75/108 | 1/0 | Met306Ile in embB. | - |
| Ramaswamy SV AAC 2000 | GAC/AAC | 10 | 4 | Asp/Asn | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 40ug/ml | BACTEC 460 | 75/108 | 1/0 | Gly406Asp in embB | - |
| Ramaswamy SV AAC 2000 | GCG/ACG | 601 | 201 | Ala/Thr | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 30ug/ml | BACTEC 460 | 75/108 | 1/0 | Asp328Tyr and Tyr334His in embB. | - |
| Ramaswamy SV AAC 2000 | GGC/AGC | 961 | 321 | Gly/Ser | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 10-30ug/ml | BACTEC 460 | 75/108 | 1/0 | - | - |
| Ramaswamy SV AAC 2000 | GGC/GAC | 1049 | 350 | Gly/Asp | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 10-30ug/ml | BACTEC 460 | 75/108 | 2/0 | - | - |
| Ramaswamy SV AAC 2000 | GCG/GTG | 1385 | 462 | Ala/Val | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 10-30ug/ml | BACTEC 460 | 75/108 | 1/0 | - | - |
| Ramaswamy SV AAC 2000 | GAC/GGC | 2498 | 833 | Asp/Ala | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 10-30ug/ml | BACTEC 460 | 75/108 | 1/0 | - | - |
| Ramaswamy SV AAC 2000 | CCG/TCG | 2737 | 913 | Pro/Ser | Published 2000 | USA, Russia | Sequencing | Whole gene | E | 40-50ug/ml | BACTEC 460 | 75/108 | 2/0 | "Gln351STOP in iniC at MIC=40ug/ml; Asn394Asp in embC, Gly350Asp in embA, Leu276Arg in Rv3124, and -24 G deletion in Rv0340, at MIC=50ug/ml." | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |