|
|
           
|
|
|
|
|
|
|
|
 
|
|
Rv3793 More about Rv3793 on TBDB.org More about Rv3793 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3793: Codons 300 to 324: 7 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Srivastava S JMM 2009 | ATG/CGT | 898-900 | 300 | Met/Arg | Published 2009 | India | Sequencing | Whole gene | EH | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB V360M, A431T; embC G272S, H285Y, A307T; embR A176V, I369T" | - |
| Srivastava S JMM 2009 | CGT/GGC | 904-906 | 302 | Arg/Gly | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | embC Y296S | - |
| Srivastava S JMM 2009 | GTG/GGC | 908-909 | 303 | Val/Gly | Published 2009 | India | Sequencing | Whole gene | E | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB E368A, S380R, P397Q, R460C; embC A244T, G288W; embR L172R" | - |
| Srivastava S JMM 2009 | GCG/ACC | 919-921 | 307 | Ala/Thr | Published 2009 | India | Sequencing | Whole gene | EH | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB V360M, A431T; embC G272S, H285Y, M300R; embR A176V, I369T" | - |
| Srivastava S JMM 2009 | GGC/GAT | 923-924 | 308 | Gly/Asp | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306I; embC T270I, Y296H', G325S" | - |
| Srivastava S JMM 2009 | TAT/AAC | 925-927 | 309 | Tyr/Asn | Published 2009 | India | Sequencing | Whole gene | EH | 2ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB A357S, A379T; embC V287F; embR L320V, S326N, V350G, H351Q, R356G, I369T" | - |
| Srivastava S JMM 2009 | ATG/AAA | 929-930 | 310 | Met/Lys | Published 2009 | India | Sequencing | Whole gene | EHR | 96ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB H312R, S317T, A356F, L359I, R367P; embC G288V, Y327N" | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
|
© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |