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Rv3793 More about Rv3793 on TBDB.org More about Rv3793 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3793: Codons 275 to 299: 9 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Srivastava S JMM 2009 | CAT/TAT | 853 | 285 | His/Tyr | Published 2009 | India | Sequencing | Whole gene | EH | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB V360M, A431T; embC G272S, M300R, A307T; embR A176V, I369T" | - |
| Srivastava S JMM 2009 | GTG/TTT | 859-861 | 287 | Val/Phe | Published 2009 | India | Sequencing | Whole gene | EH | 2ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB A357S, A379T; embC Y309N; embR L320V, S326N, V350G, H351Q, R356G, I369T" | - |
| Srivastava S JMM 2009 | GGC/TGG | 862-864 | 288 | Gly/Trp | Published 2009 | India | Sequencing | Whole gene | E | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB E368A, S380R, P397Q, R460C; embC A244T, V303G; embR L172R" | - |
| Srivastava S JMM 2009 | GGC/GTG | 863-864 | 288 | Gly/Val | Published 2009 | India | Sequencing | Whole gene | EHR | 96ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB H312R, S317T, A356F, L359I, R367P; embC M310K, Y327N" | - |
| Srivastava S JMM 2009 | TAT/CAT | 886-888 | 296 | Tyr/His | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB M306I; embC T270I, G308D, G325S" | - |
| Srivastava S JMM 2009 | TAT/AGC | 886-888 | 296 | Tyr/Ser | Published 2009 | India | Sequencing | Whole gene | EHR | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | embC R302G | - |
| Srivastava S JMM 2009 | ATT/TTG | 889-891 | 297 | Ile/Leu | Published 2009 | India | Sequencing | Whole gene | E | 3ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB G358V, E368Q, S380D, P397T, G406D, G448V; embC W326R" | - |
| Srivastava S JMM 2009 | ATT/CTG | 889-891 | 297 | Ile/Leu | Published 2009 | India | Sequencing | Whole gene | EHR | 48ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB V360M; embC A247P, W326R; embR V7G" | - |
| Srivastava S JMM 2009 | ATT/ACC | 890-891 | 297 | Ile/Thr | Published 2009 | India | Sequencing | Whole gene | EHR | 4ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB S347I, E368D, R460L; embR R230W, I396T" | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |