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Rv3793 More about Rv3793 on TBDB.org More about Rv3793 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3793: Codons 250 to 274: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Srivastava S CurrMicro 2006 | CTG/CGT | 752 | 251 | Leu/Arg | Published 2006 | India | Sequencing | ERDR | E, EHR, HR, EH | 12ug/ml | Proportion method, E-Test | 23/23 | 1/0 | Ala254Gly and Thr270Ile in embC. R/Tot and R/S calculated from Table 1. | - |
| Srivastava S CurrMicro 2006 | GCC/GGC | 761 | 254 | Ala/Gly | Published 2006 | India | Sequencing | ERDR | E, EHR, HR, EH | 12ug/ml | Proportion method, E-Test | 23/23 | 1/0 | Leu251Arg and Thr270Ile in embC. R/Tot and R/S calculated from Table 1. | - |
| Sreevatsan S AAC 1997 | ACC/ATC | 809 | 270 | Thr/Ile | Published 1997 | USA, Mexico, Europe, Yemen, the Philippines, Japan, India | PCR-SSCP, Sequencing | Whole gene | E | N.S. | BACTEC 460, agar diffusion method | 16/19 | 1/0 | Met306Val in embB. | - |
| Srivastava S JMM 2009 | ACC/ATT | 809-810 | 270 | Thr/Ile | Published 2009 | India | Sequencing | Whole gene | EH | 4ug/ml | Proportion method, E-Test | 44/44 | 1/0 | embB G406A | - |
| Srivastava S JMM 2009 | GGC/GAC | 814-815 | 272 | Gly/Ser | Published 2009 | India | Sequencing | Whole gene | EH | 6ug/ml | Proportion method, E-Test | 44/44 | 1/0 | "embB V360M, A431T; embC H285Y, M300R, A307T; embR A176V, I369T" | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |