Rv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1267c: embRRv3124Rv3125cRv3126Rv3264c: rmlA2Rv3266c: rmlDRv3793: embCRv3794: embARv3795: embB

Rv3793

More about Rv3793 on    TBDB.org

More about Rv3793 on    TubercuList

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Display high confidence mutations only
Rv3793: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Sreevatsan S AAC 1997 GGT/AGT 13 5 Gly/Ser Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E N.S. BACTEC 460 16/19 1/0 - -
Srivastava S JMM 2009 GCG/ACC 730-732 244 Ala/Thr Published 2009 India Sequencing Whole gene E 6ug/ml Proportion method, E-Test 44/44 1/0 "embB E368A, S380R, P397Q, R460C; embC G288W, V303G; embR L172R" -
Srivastava S JMM 2009 GCC/CCG 739-741 247 Ala/Pro Published 2009 India Sequencing Whole gene EH 8ug/ml Proportion method, E-Test 44/44 1/0 "embB A356F, A357V, L359I, E378A, A379D, Y384N, A388G, N399D; embC T270I, I297T" -
Srivastava S CurrMicro 2006 CTG/CGT 752 251 Leu/Arg Published 2006 India Sequencing ERDR E, EHR, HR, EH 12ug/ml Proportion method, E-Test 23/23 1/0 Ala254Gly and Thr270Ile in embC. R/Tot and R/S calculated from Table 1. -
Srivastava S CurrMicro 2006 GCC/GGC 761 254 Ala/Gly Published 2006 India Sequencing ERDR E, EHR, HR, EH 12ug/ml Proportion method, E-Test 23/23 1/0 Leu251Arg and Thr270Ile in embC. R/Tot and R/S calculated from Table 1. -
Sreevatsan S AAC 1997 ACC/ATC 809 270 Thr/Ile Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E N.S. BACTEC 460, agar diffusion method 16/19 1/0 Met306Val in embB. -
Srivastava S JMM 2009 ACC/ATT 809-810 270 Thr/Ile Published 2009 India Sequencing Whole gene EH 4ug/ml Proportion method, E-Test 44/44 1/0 embB G406A -
Srivastava S JMM 2009 GGC/GAC 814-815 272 Gly/Ser Published 2009 India Sequencing Whole gene EH 6ug/ml Proportion method, E-Test 44/44 1/0 "embB V360M, A431T; embC H285Y, M300R, A307T; embR A176V, I369T" -
Srivastava S JMM 2009 CAT/TAT 853 285 His/Tyr Published 2009 India Sequencing Whole gene EH 6ug/ml Proportion method, E-Test 44/44 1/0 "embB V360M, A431T; embC G272S, M300R, A307T; embR A176V, I369T" -
Srivastava S JMM 2009 GTG/TTT 859-861 287 Val/Phe Published 2009 India Sequencing Whole gene EH 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S, A379T; embC Y309N; embR L320V, S326N, V350G, H351Q, R356G, I369T" -
Srivastava S JMM 2009 GGC/TGG 862-864 288 Gly/Trp Published 2009 India Sequencing Whole gene E 6ug/ml Proportion method, E-Test 44/44 1/0 "embB E368A, S380R, P397Q, R460C; embC A244T, V303G; embR L172R" -
Srivastava S JMM 2009 GGC/GTG 863-864 288 Gly/Val Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB H312R, S317T, A356F, L359I, R367P; embC M310K, Y327N" -
Srivastava S JMM 2009 TAT/CAT 886-888 296 Tyr/His Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306I; embC T270I, G308D, G325S" -
Srivastava S JMM 2009 TAT/AGC 886-888 296 Tyr/Ser Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embC R302G -
Srivastava S JMM 2009 ATT/TTG 889-891 297 Ile/Leu Published 2009 India Sequencing Whole gene E 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, S380D, P397T, G406D, G448V; embC W326R" -
Srivastava S JMM 2009 ATT/CTG 889-891 297 Ile/Leu Published 2009 India Sequencing Whole gene EHR 48ug/ml Proportion method, E-Test 44/44 1/0 "embB V360M; embC A247P, W326R; embR V7G" -
Srivastava S JMM 2009 ATT/ACC 890-891 297 Ile/Thr Published 2009 India Sequencing Whole gene EHR 4ug/ml Proportion method, E-Test 44/44 1/0 "embB S347I, E368D, R460L; embR R230W, I396T" -
Srivastava S JMM 2009 ATG/CGT 898-900 300 Met/Arg Published 2009 India Sequencing Whole gene EH 6ug/ml Proportion method, E-Test 44/44 1/0 "embB V360M, A431T; embC G272S, H285Y, A307T; embR A176V, I369T" -
Srivastava S JMM 2009 CGT/GGC 904-906 302 Arg/Gly Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 embC Y296S -
Srivastava S JMM 2009 GTG/GGC 908-909 303 Val/Gly Published 2009 India Sequencing Whole gene E 6ug/ml Proportion method, E-Test 44/44 1/0 "embB E368A, S380R, P397Q, R460C; embC A244T, G288W; embR L172R" -
Srivastava S JMM 2009 GCG/ACC 919-921 307 Ala/Thr Published 2009 India Sequencing Whole gene EH 6ug/ml Proportion method, E-Test 44/44 1/0 "embB V360M, A431T; embC G272S, H285Y, M300R; embR A176V, I369T" -
Srivastava S JMM 2009 GGC/GAT 923-924 308 Gly/Asp Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306I; embC T270I, Y296H', G325S" -
Srivastava S JMM 2009 TAT/AAC 925-927 309 Tyr/Asn Published 2009 India Sequencing Whole gene EH 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S, A379T; embC V287F; embR L320V, S326N, V350G, H351Q, R356G, I369T" -
Srivastava S JMM 2009 ATG/AAA 929-930 310 Met/Lys Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB H312R, S317T, A356F, L359I, R367P; embC G288V, Y327N" -
Srivastava S JMM 2009 GGC/AGC 973 325 Gly/Ser Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB M306I; embC T270I, Y296H, G308D" -
Srivastava S JMM 2009 TGG/CGT 976-978 326 Trp/Arg Published 2009 India Sequencing Whole gene E 3ug/ml Proportion method, E-Test 44/44 1/0 "embB G358V, E368Q, S380D, P397T, G406D, G448V; embC I297L" -
Srivastava S JMM 2009 TAT/AAC 979-981 327 Tyr/Asn Published 2009 India Sequencing Whole gene EHR 96ug/ml Proportion method, E-Test 44/44 1/0 "embB H312R, S317T, A356F, L359I, R367P; embC G288V, M310K" -
Ramaswamy SV AAC 2000 AAC/GAC 1180 394 Asn/Asp Published 2000 USA, Russia Sequencing Whole gene E 50ug/ml BACTEC 460, agar diffusion method 75/108 1/0 "Gly350Asp and Pro913Ser in embA; Leu276Arg in Rv3124; -12 G deletion in Rv0340." -
Ramaswamy SV AAC 2000 CGG/CAG 2213 738 Arg/Gln Published 2000 USA, Russia Sequencing Whole gene E N.S. BACTEC 460, agar diffusion method 75/108 1/0 "-16 C/T in embA; Met306Ile in embB, Pro54Ser in RV3124." -
Sreevatsan S AAC 1997 GTG/CTG or GTG/TTG 2941 981 Val/Leu Published 1997 USA, Mexico, Europe, Yemen, the Philippines, Japan, India PCR-SSCP, Sequencing Whole gene E 15ug/ml BACTEC 460, agar diffusion method 16/19 - All three isolates also had a synonymous G/A substitution at nt 2898 of embA. -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator